Sensitive Bioanalysis of Antisense Oligonucleotides of Various Lengths and Modifications

T1530 ‐09‐54 Sensitive Bioanalysis of Antisense Oligonucleotides through Mitigation of Non‐specific Binding and Improved LC‐MS/MS Performance Suma Veeramachineni, Mark D Wrona Waters Corporation, Milford, MA CONTACT INFORMATION: [email protected]; [email protected] PURPOSE RESULT(S) Improving LC-MS/MS bioanalytical performance especially for ESI negative analytes…

Application Note Sensitive LC-MS/MS Bioanalytical Quantitation of Antisense Oligonucleotides Suma Veeramachineni, Mark D. Wrona Waters Corporation Abstract This application demonstrates the quantitative and qualitative capabilities of the Waters™ Xevo™ TQ Absolute Tandem Quadrupole Mass Spectrometer (MS/MS) and its suitability for…

[ APPLICATION NOTEBOOK ] Versatile LC-MS/MS Solutions for the Evolving Bioanalysis Landscape Small Molecules Oligonucleotide Protein/Peptide Therapeutics Software Tools Targeted Imaging LC-MS/MS Solutions to Support Reliable, Sensitive and Efficient Workflows for the Bioanalysis of Drug Modalities Welcome to the Waters…

Improving LC-MS/MS Bioanalytical Quantitation of Oligonucleotides using New High Performance Tandem Quadrupole Mass Spectrometer Suma Veeramachineni1; Suraj Dhungana1; Ying-Qing Yu1; Mark Wrona1; 1Waters Corporation, Milford, MA Introduction Results Improving LC-MS/MS bioanalytical performance especially for ESI negative analytes has been of…