N-methylpyrrolidone impurity in Cefepime Hydrochloride

Application Note 199 Determination of N-Methylpyrrolidine in Cefepime Using a Reagent-Free Ion Chromatography System Introduction Cephalosporins are currently the most prescribed class of antibiotics worldwide for the treatment of bacterial infections.1 Their low toxicity and broad range antimicrobial activity against…

Application Note 259 Determination of N-Methylpyrrolidine in Cefepime with Nonsuppressed Conductivity Detection INTRODUCTION Cefepime (Figure 1A) is a semi-synthetic, fourthgeneration cephalosporin with low toxicity and a broad antimicrobial activity range against Gram-negative and Gram-positive bacteria.1, 2 However, this antibiotic is…

Application Note 205 Determination of Cefepime and CefepimeRelated Substances Using HPLC with UV Detection Introduction Cephalosporins are currently among the most widely prescribed antibiotics in hospitals.1 Development of these antibiotics has led to compounds with a broad spectrum of activity…

Thunyarat Phesatcha,1 Suparerk Tukkeeree,1 and Jeff Rohrer2 Thermo Fisher Scientific, Bangkok, Thailand; 2Thermo Fisher Scientific, Sunnyvale, CA, USA 1 Key Words Pharmaceutical, Dionex IonPac CS19 Column, Reagent-Free Ion Chromatography Introduction Methylamine or monomethylamine (MMA) is widely used in different stages…