Orbitrap Exploris 240 mass spectrometer delivers significantly increased lab productivity and reproducibility of human plasma proteome profiling from large human cohort studies

An Ultra High-throughput Plasma Protein Profiling (uHTPPP) Workflow Using a Modified Quadrupole-Orbitrap Mass Spectrometer Michelle L. Dubuke1, Sarah Trusiak1, Sitara Chauhan1, Ryan D. Bomgarden2, Sergei Snovida2, Bhavin Patel2, Emily I. Chen1. 1Thermo Fisher Scientific, Precision Medicine Science Center, Cambridge, MA.…

Proof of performance Orbitrap Exploris 240 mass spectrometer Plasma profiling–reliable large cohort analysis with a fully automated workflow Summary Here we present an Ultra-High Throughout Plasma Protein Profiling (uHTPPP) workflow (Figure 1), from automated sample preparation to high-resolution, accurate-mass (HRAM)…

WHITE PAPER 65937 Grant Application Resource Accelerating high-confidence insights for small- and large-molecule research using the Orbitrap Exploris 240 mass spectrometer Authors: Maciej Bromirski, Aaron Robitaille, Thermo Fisher Scientific, San Jose, CA, USA Keywords: Orbitrap Exploris 240 Mass Spectrometer, FAIMS…

APPLICATION NOTE 65727 Sampling the human population – ultra-highthroughput plasma protein profiling (uHTPPP) sample preparation for translational proteomics Authors: Sarah Trusiak,1 Sergei Snovida,2 Bhavin Patel,2 Ryan Bomgarden,2 Emily I. Chen,1 1 Thermo Fisher Scientific Precision Medicine Science Center, Cambridge, MA,…