Identification and quantitation of oligonucleotides, impurities, and degradation products

APPLICATION NOTE 73789 Oligonucleotide mapping using BioPharma Finder software Authors: Haichuan Liu1, Kevin Guo2, Jennifer Sutton1, Min Du2 Thermo Fisher Scientific, San Jose, CA Thermo Fisher Scientific, Boston, MA 1 2 Keywords: Oligonucleotide, DNA, RNA, data dependent acquisition, tandem mass…

APPLICATION BRIEF 74058 Characterization of a synthetic double stranded siRNA using high-resolution mass spectrometry Authors: Haichuan Liu1, Kevin Guo2, Julia Baek3, Jennifer Sutton1, Keeley Murphy1, Min Du2 Thermo Fisher Scientific, San Jose, CA 1 2 Thermo Fisher Scientific, Cambridge, MA…

Application note | 001398 Biopharma Streamlining characterization and monitoring of oligonucleotide impurities using an Orbitrap-based LC-HRAM-MS platform Application benefits Authors Hao Yang , Keeley Murphy , Yi Zhang , 1 2 3 • Comprehensive characterization of oligonucleotides and their impurities…

Application note | 001108 Biopharma Characterization of mRNA 5’ capping products using an LC-HRAM-MS/MS analytical platform and Thermo Scientific BioPharma Finder software solution Authors Goal Robert L Ross, Keeley Murphy, Yi Zhang, To develop a sensitive and robust LC-HRAM-MS/MS method…