Characterization of monoclonal antibodies and antibody drug conjugates using iCIEF-MS online coupling platform

Imaged capillary isoelectric focusing – Mass Spectrometry (iCIEF- MS) online coupling for polatuzumab vedotin charge heterogeneity analysis using native MS Xiaoxi Zhang1, Tony Chen2, Tao Bo2, Tiemin Huang2, Min Du3. 1 Thermo Fisher Scientific, Shanghai, China, 2 Advanced Electrophoresis Solutions…

Agilent BioHPLC columns Characterization of Antibody-Drug Conjugate Critical Quality Attributes Application compendium Contents Introduction3 Featured application notes 2 PLRP-S Polymeric Reversed-Phase Column for LC/MS Separation of mAbs and ADC (5991-7163EN) 5 Intact- and Peptide-Level Characterization of Trastuzumab Emtansine In Vitro…

Size Exclusion Chromatography/ Mass Spectrometry Analysis of Antibody Drug Conjugates Using the Agilent 1260 Infinity II Bio-Inert LC Application Note Biologics & Biosimilars Author Abstract Sonja Schneider Recombinant monoclonal antibodies (mAbs) have emerged as important Agilent Technologies, Inc. therapeutic agents…

Analysis of Antibody-Drug Conjugates Using Size Exclusion Chromatography and Mass Spectrometry Application Note Biologics and Biosimilars Author Abstract Sonja Schneider Recombinant monoclonal antibodies (mAbs) have emerged as important Agilent Technologies, Inc. therapeutic agents for the treatment of different diseases. This…