A COMPARISON OF CONVENTIONAL AND RAPID GRADIENT MICROBORE LC CYCLIC™ ION MOBILITY MASS SPECTROMETRY FOR NON-TARGETED SCREENING OF BIOLOGICAL MATRICES

Application Note High Throughput Non-Targeted Screening Using a Rapid Gradient Microbore UPLC Method and a Library of FDA-Approved Small Molecule Drugs Michael McCullagh, Jeff Goshawk, Russell J. Mortishire-Smith Waters Corporation Abstract Rapid gradient microbore UltraPerformance Liquid Chromatography was combined with…

Application Note Retention Time, Product Ion, and CCS Characterization of the Constituents of a FDA-Approved Small Molecule Pharmaceuticals Library Michael McCullagh, Jeff Goshawk, Russell J. Mortishire-Smith Waters Corporation Abstract A set of FDA-approved small molecule pharmaceuticals was used to produce…

INVESTIGATIONS INTO CROSS-PLATFORM AND LONG-TERM ROBUSTNESS OF A CCS METRIC Michael McCullagh1; Michelle Wood1; Nayan Mistry1; Martin Palmer1;Severine Goscinny2; David Douce1 and Petur Dalsgaard3 1 Waters Corporation, Wilmslow, United Kingdom; 2Sciensano, 14, rue Juliette Wytsman, Belgium; 3Department of Forensic Medicine,…

[ APPLICATION NOTE ] Small Molecule Ion Mobility Investigations into Cross-platform and Long-term Robustness of a CCS Metric Mike McCullagh, 1 Michelle Wood, 2 Nayan Mistry, 2 Severine Goscinny, 3 Petur Dalsgaard4 Waters Corporation, Wilmslow, UK; 2 Sciensano, Brussels, Belgium;…