Validating Analytical Methods with Charged Aerosol Detection

Improving the Quantitation of Unknown Impurity Analysis Using Dual-Gradient HPLC with Charged Aerosol Detection Christopher Crafts, Bruce Bailey, Marc Plante, John Waraska, and Ian Acworth ESA—A Dionex Company, Chelmsford, MA USA ABSTRACT INTRODUCTION Quantification of substances such as drug impurities…

Table of contents Summary Overview Excipient function Measurement Charged Aerosol Detector Universal detection Uniform response Working principles (U)HPLC Systems with CAD Columns choice Excipients overview Adjuvants Amino acids Carbohydrates Counterions Nonionic surfactants Polyethylene glycol Proteins and excipients HPLC-Charged Aerosol Detection…

Improving the Quantitation of Unknown Trace Impurity Analysis of Active Pharmaceutical Ingredients Using HPLC with Charged Aerosol Detection Kannan Srinvasan1, Marc Plante2, Chris Crafts2, Ian Acworth2, Paul Gamache2, and John Waraska2 Dionex Corporation, Sunnyvale, CA, USA; 2ESA––A ESA—A Dionex Company,…

PRODUCT SPECIFICATIONS 22083 Acclaim Trinity P1 column Superior pharmaceutical and counterion separations The Thermo Scientific™ Acclaim™ Trinity™ P1 is a unique, high-efficiency, silica-based column with both reversed-phase and ion-exchange functionality. These columns are specifically designed for simultaneous separation of anions,…