IICS: Improving the Quantitation of Unknown Trace Impurity Analysis of Active Pharmaceutical Ingredients Using HPLC with Charged Aerosol Detection

Improving the Quantitation of Unknown Impurity Analysis Using Dual-Gradient HPLC with Charged Aerosol Detection Christopher Crafts, Bruce Bailey, Marc Plante, John Waraska, and Ian Acworth ESA—A Dionex Company, Chelmsford, MA USA ABSTRACT INTRODUCTION Quantification of substances such as drug impurities…

Charged Aerosol Detection 101 Dr. Alexander Schwahn European Sales Support Expert for Biopharma Industry Thermo Fisher Scientific, Reinach, Switzerland The world leader in serving science Outline • • • • • • 2 Introduction to charged aerosol detection (CAD) How…

Discover what you’re missing Thermo Scientific Charged Aerosol Detectors Hidden peaks revealed The analyte detection challenge No single liquid chromatography (LC) detector delivers ideal results. Often, one analyte responds more strongly than another, or may not respond at all. What…

Table of contents Summary Overview Excipient function Measurement Charged Aerosol Detector Universal detection Uniform response Working principles (U)HPLC Systems with CAD Columns choice Excipients overview Adjuvants Amino acids Carbohydrates Counterions Nonionic surfactants Polyethylene glycol Proteins and excipients HPLC-Charged Aerosol Detection…