Analysis of Phosphorothioate Oligonucleotides

C190-E294 High Performance Liquid Chromatography Columns Shim-pack HPLC Columns for Bioseparation Ion Exchange Chromatography Columns Shim-packTM Bio IEX P. 7 Hydrophobic Interaction Chromatography Columns Shim-pack Bio HIC P. 7 Size Exclusion Chromatography Columns Shim-pack Bio Diol P. 8 Reversed Phase…

High Performance Liquid Chromatograph Mass Spectrometer Application News Analysis of Oligonucleotide Impurities Using Single Quadrupole Mass Spectrometer Mizuki Hayakawa, Hiroyuki Niwa User Benefits  Combination use of LCMS-2050 single quadrupole mass spectrometer and LabSolutions Insight Biologics provides comprehensive characterization of…

Application News No. C215 LC-MS Determination of Molecular Mass and Quantification of Oligonucleotide Therapeutics Using Quadrupole Time-of-Flight Mass Spectrometer LCMS™-9030  Overview Oligonucleotide therapeutics are synthetic oligonucleotides that demonstrate their medical efficacy through binding to target genes or target proteins…

WP 459 Qualification and Quantitation of Phosphorothioate Oligonucleotides Using a Quadrupole-Time-of-Flight Mass Spectrometer Noriko Kato, Yusuke Inohana, Tairo Ogura, Masaki Yamada, Toshiya Matsubara Shimadzu Corporation. 1, Nishinokyo-Kuwabaracho Nakagyo-ku, Kyoto 604–8511, Japan 3. Methods 1. Overview The purpose of this study…