INTACT Mass™ - a Versatile waters_connect™ Application for Rapid Mass Confirmation and Purity Assessment of Biotherapeutics

[ APPLICATION NOTEBOOK ] Multi-Attribute Methods for Biopharmaceutical Analysis Application Notes [ APPLICATION NOTEBOOK ] Introduction The adoption of LC-MS-based multi-attribute method (MAM) analysis for routine monitoring of biotherapeutic variation has progressed greatly over the last five years. The ability…

Application Note Multi-Reflecting Time of Flight-MS: A Novel Technology for In-depth mAb Subunit Characterization Jonathan Fox, Ying Qing Yu, Scott J. Berger, Nick Pittman Waters Corporation Application Brief This is an Application Brief and does not contain a detailed Experimental…

Application Note Advancing ADC Characterization: SECBased Native DAR and Drug Distribution Analysis Using Multi-Reflecting TOF-MS and INTACT Mass Application Jonathan Fox, Scott J Berger, Laetitia Denbigh, Sam Ippoliti Waters Corporation, United States Published on December 24, 2025 Abstract This technology…

Application Note Accelerating GLP-1 Development with HighThroughput LC-MS Using the BioAccord™ LC MS System and the INTACT Mass Application Jonathan Fox, Laetitia Denbigh, Scott Berger, Nick Pittman Waters Corporation, United States Published on December 17, 2025 Abstract High-quality analysis of…