Activated-Ion Electron Transfer Dissociation Enables Electron-Based Dissociation Following Proton Transfer Charge Reduction

Infrared Activation Enables Native Top-Down MS Analysis of Membrane Proteins and Protein Complexes Joshua D Hinkle1, Tarick J El-Baba2, Corinne A Lutomski2, Idlir Liko3, Jani Reddy Bolla2, Carol V Robinson2, and John EP Syka1, 1Thermo Fisher Scientific, 355 River Oaks…

APPLICATION NOTE 74160 Proton transfer charge reduction (PTCR) improves spectral matching and sequence coverage in middle-down analysis of monoclonal antibodies Luca Fornelli,1 Ryan N. Oates,1 Kristina Srzentić,2 Christopher Mullen,3 John E. P. Syka,3 and Romain Huguet3 University of Oklahoma, Norman,…

WHITE PAPER 65971 Grant application resource Go beyond today’s discovery with the Orbitrap Eclipse Tribrid mass spectrometer Keywords: Orbitrap Eclipse Tribrid Mass Spectrometer, FAIMS Pro Interface, Mass Spectrometry, Quantitative Proteomics, TMT and TMTpro Multiplexing, Single-cell Sensitivity, Top-down Proteomics, Native Intact…

Product specifications | 004346 Mass spectrometry Rise to the molecular challenges of today and tomorrow Orbitrap Tribrid Apex BioPharma mass spectrometer Benefits • Preserves native protein aggregates with enhanced ion decluttering via IR-laser desolvation • Single-platform versatility for intact biologics,…