TIDES 2021: BioAccord with UNIFI for Oligonucleotide Identity, Assay, Purity and Impurities Quantification

Application Note Workflow for Profiling Impurities in Synthetic Oligonucleotides Using the BioAccord™ LCMS System with waters_connect™ Informatics Kellen DeLaney, Jo-Anne Riley, Jonathan Fox, Heidi Gastall, Laetitia Denbigh, Ying Qing Yu Waters Corporation This is an Application Brief and does not…

Application Note Rapid LC-UV/MS Workflow for Routine Oligonucleotide Impurity Monitoring Using the SQ Detector 2 Mass Detector and Empower™ Chromatography Data System (CDS) Henry Foddy, Victoria van Kuijk, Jo-Anne Riley, Cristian Cojocariu Waters Corporation, Wilmslow, United Kingdom Published on August…

[ APPLICATION NOTEBOOK ] Multi-Attribute Methods for Biopharmaceutical Analysis Application Notes [ APPLICATION NOTEBOOK ] Introduction The adoption of LC-MS-based multi-attribute method (MAM) analysis for routine monitoring of biotherapeutic variation has progressed greatly over the last five years. The ability…

Application Note LC-MS Analysis of siRNA, Single Guide RNA and Impurities Using the BioAccord™ System with ACQUITY™ Premier and New Automated INTACT Mass Application Catalin E. Doneanu, Patrick Boyce, Henry Shion, Joseph Fredette, Scott J. Berger, Heidi Gastall, Ying Qing…