Application Note A Xevo™ G3-based Workflow for Purity Determination, Intact Mass Measurement, and MS/MS Sequencing of Impurities Detected in Synthetic Oligonucleotides Catalin E. Doneanu, Jonathan Fox, Brad J. Williams, Chris Knowles, Ying Qing Yu Waters Corporation Abstract This study evaluates…
Application Note LC-MS Analysis of siRNA, Single Guide RNA and Impurities Using the BioAccord™ System with ACQUITY™ Premier and New Automated INTACT Mass Application Catalin E. Doneanu, Patrick Boyce, Henry Shion, Joseph Fredette, Scott J. Berger, Heidi Gastall, Ying Qing…
Application Note Rapid LC-UV/MS Workflow for Routine Oligonucleotide Impurity Monitoring Using the SQ Detector 2 Mass Detector and Empower™ Chromatography Data System (CDS) Henry Foddy, Victoria van Kuijk, Jo-Anne Riley, Cristian Cojocariu Waters Corporation, Wilmslow, United Kingdom Published on August…
Application Note 100 Samples per Hour: High-Speed Oligonucleotide Analysis with BioAccord™ LC-MS and INTACT Mass Application Jonathan Fox, Laetitia Denbigh, Scott Berger, Kate Yu Waters Corporation, United States Published on November 27, 2025 Abstract The development of oligonucleotide therapeutics requires…
