Analyzing Monoclonal Antibody (mAb) Fragments and Dimers Using Size Exclusion Chromatography (SEC)

Consumables Workflow Ordering Guide Analyzing Monoclonal Antibody (mAbs) and mAb-Derived Therapeutics Using Native SEC-MS The quantitation of aggregates is of particular concern for protein-based-therapies given their potential effect on efficacy and immunogenicity. Size exclusion chromatography (SEC) combined with UV detection…

Consumables Workflow Ordering Guide Improving the Quality of Antibody Drug Conjugates by Orthogonal Analytical Methods Antibody Drug Conjugates Antibody-drug conjugates (ADCs) represent a new generation of targeted biotherapeutics that make up a rapidly growing segment of the drug discovery pipeline.…

Consumables Workflow Ordering Guide Aggregate Analysis of Adeno-Associated Viruses and Virus-Like Particles in Biopharma by Liquid Chromatography Adeno-associated viruses (AAVs) and virus-like particles (VLPs) are emerging biotherapeutic molecules with exciting potential in the vaccine, cell, and gene therapy spaces. AAVs…

Helpful ‘Hints’ for Protein SEC Success Jean Lane Applications Engineer LC columns and consumables technical support May 27, 20201 Outline for Talk Getting started • SEC definition, common terminology, and why use it? • Considerations for selecting an SEC column…