Oligonucleotides analysis by Ion Exchange Chromatography and Effects of pH Changes in the Mobile Phase on Separation

C10G-E097 Oligonucleotide Therapeutics Solution Guide Types and Characteristics of Oligonucleotide Therapeutics Oligonucleotide therapeutics are nucleic acid polymers generally comprised of a few to several dozen bases However, it is a practical problem that oligonucleotide therapeutics are degraded and excreted rapidly…

High Performance Liquid Chromatography / NexeraTM XS inert Application News DMT-on Purification of Phosphorothioate Oligonucleotide Using SHIMSENTM Styra HLB SPE Cartridge Derrick Tan User Benefits  A simple and straightforward workflow for purification of modified phosphorothioate oligonucleotide.  Stability of…

Application News LabSolutions™ MD : Software for Efficient Method Development based on Analytical Quality by Design Efficient Method Development of Oligonucleotides by Reversed-Phase Ion-Pair Chromatography Shinichi Fujisaki and Risa Suzuki User Benefits  LabSolutions MD can improve the efficiency of…

High Performance Liquid Chromatograph Mass Spectrometer Application News Analysis of Oligonucleotides Using a Single Quadrupole Mass Spectrometer with Hydrophilic Interaction Chromatography (HILIC) Mizuki Hayakawa, Noriko Kato, Kosuke Uchiyama User Benefits  Synthetic oligonucleotides and impurities can be analyzed using HILIC.…