Experimental Strategies to Improve Drug-target Identification in Mass Spectrometry-based Thermal Stability Assays

APPLICATION NOTE 65729 Real-Time Search enables a new gold standard for TMT quantitation accuracy on the Orbitrap Eclipse Tribrid mass spectrometer Authors: Aaron M. Robitaille1, Romain Huguet1, Ryan Bomgarden2, Jesse D. Canterbury1, Daniel Lopez-Ferrer1 Thermo Fisher Scientific, San Jose, CA…

Software development for improved sensitivity of mass spectrometry-based thermal shift assays (MS-TSA) for target engagement and drug discovery Amanda M. Figueroa-Navedoa, Clifford Phaneufab, Konstantin Aizikovc, Alexander R. Ivanova a Department of Chemistry and Chemical Biology, Barnett Institute of Chemical and…

Performance Evaluation of a Modified Quadrupole Orbitrap Mass Spectrometer Tabiwang N. Arrey1, Rosa Jersie-Christensen Rakownikow1, Julia Kraegenbring1, Kerstin Strupat1, Markus Kellmann1, Catharina Crone1, Thomas Moehring1, Alexander Harder1 1Thermo Fisher Scientific, Bremen, Bremen, Germany Results: The novel Orbitrap Exploris 480 mass…

POSTER NOTE 65541 Improved Identification, Improved Identification, Quantification Accuracy, and Workflow Q Efficiency using a Modified Quadrupole Orbitrap Mass and Ta Mass Spectrometer Aaron M. Robitaille N. Arrey 2, Markus Kellma Spectrometer and Tandem Mass Tags1, Tabiwang (TMT) Approach 1…