Extending the mass limit of collision cross sections of proteins in Orbitrap analyzers through kinetic energy and fragmentation behavior analysis

peak coalescence and resolution. W le (O lim m slo m Methods: A Thermo ScientificTM OrbitrapTM FusionTM TribridTM mass spectrometer was modified by (1) improvements to the vacuum system aimed at reducing the amount of gas in the ion injection…

James D. Determination of collision cross sections of proteins using frequency domain linewidths and time domain decay profile fitting of MS1 data from an Orbitrap mass spectrometer 1 Sanders, Virginia K. 1 James, 1The Arbitrary units Methods and Instrumentation FFT…

Ion Mobility-Mass Spectrometry Reveals the Structures and Stabilities of Biotherapeutic Antibody Aggregates % Daniel D. Vallejo1, Chae K. Jeon1, Kristine F. Parson1, Hayley Herderschee1, Joseph D. Eschweiler2, Ruwan T. Kurulugama3, John C. Fjeldsted3, Dana Filoti2, Brandon T. Ruotolo1 m/z 1Department…

Interference of adjacent ion signals in CDMS: the effect on charge accuracy and potential correction algorithms Liangxuan Fu, Michael P. Goodwin, Dmitry Grinfeld, Kyle P. Bowen, Michael W. Senko, Thermo Fisher Scientific, 355 River Oaks Pkwy, San Jose, CA, USA,…