Rapid Analysis of Synthetic mRNA Cap Structure using Ion Pairing Reversed Phase Liquid Chromatography coupled to Mass Spectrometry

Application Note Rapid Analysis of Synthetic mRNA Cap Structure Using Ion-Pairing RPLC with the BioAccord LC-MS System Jennifer M. Nguyen, Siu-Hong Chan, Bijoyita Roy, Martin Gilar, Brett Robb, Weibin Chen, Matthew A. Lauber Waters Corporation, New England Biolabs Inc. Abstract…

Application Note Biopharma/Pharma Determining mRNA Capping with HILIC-MS on a Low-Adsorption Flow Path Limiting interfering interactions with metal using the Agilent 1290 Infinity II Bio LC System Authors Gerd Vanhoenacker, Kris Morreel, Stefanie Jonckheere, Pat Sandra, and Koen Sandra RIC…

Application Note Biopharma Rapid Analysis of mRNA 5' Capping with High Resolution LC/MS Author Brian Liau Agilent Technologies, Inc. Introduction Industrial-scale production of mRNA has received growing attention due to the ongoing SARS-CoV-2 pandemic. mRNA vaccines have proven to be…

Application Note Head to Tail Analysis of mRNA by RapiZyme™ MC1 and Cusativin Alexandre F. Gomes*, Tatiana Johnston*, Balasubrahmanyam Addepalli * Equal contribution Waters Corporation, United States Published on August 10, 2026 Abstract Head to Tail Analysis of mRNA by…