Determining mRNA Capping with HILIC-MS on a Low-Adsorption Flow Path

Application Note Biopharma HILIC Analysis of CRISPR-Cas9 Gene Editing Tools on a Low Adsorption LC Flow Path Using the Agilent 1290 Infinity III Bio LC System and Ultra-Inert Column Hardware Authors Abstract Helena Vanluchene, Jelle De Vos, Kris Morreel, Pat…

Application Note Biopharma mRNA Mapping with IP-RPLC-MS on a Low-Adsorption Flow Path Using an Agilent 1290 Infinity II Bio LC System Authors Abstract Helena Vanluchene, Kris Morreel, Jelle De Vos, Pat Sandra, and Koen Sandra RIC group, President Kennedypark 6,…

Application Note Biopharma Rapid Analysis of mRNA 5' Capping with High Resolution LC/MS Author Brian Liau Agilent Technologies, Inc. Introduction Industrial-scale production of mRNA has received growing attention due to the ongoing SARS-CoV-2 pandemic. mRNA vaccines have proven to be…

Optimizing Oligonucleotide Analysis Oligonucleotide therapeutics are small synthetic nucleic acids that can be used to treat different types of diseases. They act by modulating either gene expression or protein function by binding specific genetic sequences or target proteins.1,2 Due to…