High-throughput experimentation reaction monitoring and analysis of chemistry synthesis products with ultrahigh-throughput 4D timsTOF fleX MALDI-2 technology

Intensity (arb. unit) 132% 0% 100% PS 38:1 m/z 816.5747 ± 0.0122 1/K0 1.433 ± 0.01 Intensity (arb. unit) Mobility [1/K0] 136% 0% 100% PE 20:1_22:6 m/z 816.5517 ± 0.0122 1/K0 1.404 ± 0.01 m/z 1 mm CCS-aware SpatialOMx® enables…

Next-generation MALDI top-down sequencing of protein biotherapeutics – expanding the scope of timsTOF technology Next-generation MALDI top-down sequencing (MALDI-TDS) improves top-down sequence analysis of biopharmaceutical proteins, as demonstrated in this note for adalimumab subunits, recombinant SARS-CoV-2 S-glycoprotein RBD expression products,…

TIMS enabled quantification of small molecules in MALDI Imaging timsTOF fleX was used to demonstrate quantitative mass spectrometry imaging on several drug compounds. Abstract timsTOF fleX was able to separate near-isobaric ions by their ion mobilities, significantly improving targeted compound…

LI F E S CI E N CE S M AS S S P E CTR O M E TR Y Integrated annotation pipeline using in-silico prediction for on-target chemical derivatization MALDI Imaging Arne Behrens1, Nikolas Kessler1, Sofie Weinkouff1, Bram…