PROBING SITE-SPECIFIC INTERACTIONS BETWEEN EPIDERMAL GROWTH FACTOR RECEPTOR AND AN ADNECTIN USING HDX-ETD MS APPROACH

DynamX HDX Data Analysis Software 3.0 Simplifying Hydrogen Deuterium Exchange Interpretation P ROT EIN CONFORMAT ION ANALYSIS MADE SIM P LE In HDX MS studies, replicate data are collected across multiple time points and varied species (native vs. mutant, innovator…

LOCALIZED CONFORMATION ANALYSES OF MUTATED HUMAN IgG1 BY HYDROGEN DEUTERIUM EXCHANGE MASS SPECTROMETRY AND DIFFERENTIAL SCANNING CALORIMETRY Joomi Ahn 1, Xiaojun Lu2, Colette Quinn3, St John Skilton1, Ying Qing Yu1, and Jihong Wang2 1 Waters Corporation, 2 MedImmune, 3TA Instruments…

Poster # P-I-0178 Probe the protein conformation using top-down hydrogen exchange mass spectrometry at higher resolution with electron transfer dissociation Yuqi Shi1, Graeme McAlister1, Rosa Viner1, 1Thermo Fisher Scientific, San Jose, CA Abstract Results Purpose: Study protein, protein/complex conformations by…

WHITE PAPER 65872 Hydrogen deuterium exchange mass spectrometry for the masses Executive summary Determining the shape and dynamics of proteins and protein complexes is crucial to understanding protein function and the roles proteins play in biological systems. Traditional techniques employed…