Automatic Protein Disulfide Bond Mapping of a Monoclonal Antibody Using the Agilent Accurate-Mass Q-TOF LC/MS Platform and BioConfirm Software Algorithm

Technical Overview Highly Confident Peptide Mapping of Protein Digests Using Agilent LC/Q‑TOFs Authors Introduction Stephen Madden, Crystal Cody, and Jungkap Park Agilent Technologies, Inc. Santa Clara, California, USA The biopharmaceutical industry is adding an increasing number of protein therapeutics to…

Application Note Peptide Mapping of Trastuzumab Tryptic Digests on an Agilent 6545XT AdvanceBio LC/Q-TOF Author Stephen Sciuto, PhD Agilent Technologies, Inc. Abstract This application note describes a peptide mapping strategy to analyze tryptic digests of trastuzumab on an Agilent 6545XT…

Agilent BioHPLC Columns Characterization of NIST Monoclonal Antibody Critical Quality Attributes Application Compendium Contents Agilent-NISTmAb Standard (P/N 5191-5744; 5191-5745) was aliquoted from NISTmAb RM 8671 batch. Quality control (QC) testing is performed using Agilent LC-MS system. QC batch release test…

Application News AD-0190 Biopharma / LCMS-9030 Characterization of C-terminal and Disulfide Bond Peptides of Monoclonal Antibody (mAb) on Q-TOF Mass Spectrometer Udi Jumhawan and Zhaoqi Zhan Application Development & Support Centre, Shimadzu (Asia Pacific), Singapore 1. Introduction In recent years,…