Assessing metabolic profiles in chimeric PXB mouse with humanized livers following oral dosing of troglitazone. Alan Barnes1; Neil J Loftus1; Kirsten Hobby1; Ian Wilson2; Yoshio Morikawa3 1Shimadzu MS/BU, Manchester, UK; 2Astra Zeneca, Alderley Park, Cheshire, UK; 3PhoenixBio Co. Ltd, Higashi-Hiroshima,…
Identifying changes in ethanol metabolism and endogenous metabolic profiles following the administration of alcohol as a liquid diet to mice Simon Ashton1; Neil J Loftus1; Alan Barnes1; Ian D Wilson2; Filippos Michopoulos2; Ji Cheng3 1Shimadzu MS/BU, Manchester, UK; 2Astra Zeneca,…
PO-CON1251E Systems based LC-MS metabolite profiling of mice treated with ethanol enriched liquid diets IMSC 2012 PWe-095 Simon Ashton1; Neil J Loftus1; Alan Barnes1; Ian D Wilson2; Filippos Michopoulos2; Ji Cheng3 1 Shimadzu MS/BU, Manchester, UK; 2 Astra Zeneca, Alderley…
CORRELATING DIFFERENTIAL ENDOGENOUS METABOLITE PROFILES WITH THE PHARMACOKINETICS OF GEFITINIB AND ITS ASSOCIATED DRUG METABOLITES USING AN ION MOBILITY BASED APPROACH Lee A. Gethings1, Martin Palmer1, Adam King1, Lauren Mullin1, Ian D. Wilson2, Robert S. Plumb3 1 Waters Corp., Wilmslow,…
