CORRELATING DIFFERENTIAL ENDOGENOUS METABOLITE PROFILES WITH THE PHARMACOKINETICS OF GEFITINIB AND ITS ASSOCIATED DRUG METABOLITES USING AN ION MOBILITY BASED APPROACH

Application Note LipidQuan™: A Robust LC-MS/MS Methodology for Rapidly Profiling the Lipidome of Liver Tissue Following Metabolism of the Drug Gefitinib Nyasha Munjoma, I.D. Wilson, Lee A. Gethings, Robert S. Plumb Waters Corporation For research use only. Not for use…

LIPIDOMIC AND DESI IMAGING STUDY OF MOUSE LIVER DOSED WITH A TYROSINE KINASE INHIBITING DRUG Nyasha Munjoma 1 , Giorgis Isaac 2 , Mark Towers 1 , Emmanuelle Claude 1 , Ian D Wilson 3 , Lee A. Gethings 1…

Application Note Visualization of Gefitinib and Related Metabolites in Rat Liver Using DESI-Tandem Quadrupole Mass Spectrometry Robert Plumb, Anthony Midey Waters Corporation, United States Published on August 07, 2026 Abstract Detection and measurement of drugs, their metabolites, and biomarkers in…

Application Note Rapid Identification of the In Vivo Biotransformations of a Targeted Protein Degrader (PROTACs) Using Xevo G3 QTof and waters_connect Software Platform Robert S. Plumb Waters Corporation, United States Published on June 05, 2025 Contact Sales Abstract PROteolysis TArgeting…