Analysis of mRNA Poly-A Sequence Variants by High-Resolution LC/MS

Application Note Biopharma Rapid Analysis of mRNA 5' Capping with High Resolution LC/MS Author Brian Liau Agilent Technologies, Inc. Introduction Industrial-scale production of mRNA has received growing attention due to the ongoing SARS-CoV-2 pandemic. mRNA vaccines have proven to be…

Application note | 001183 Biopharma Characterization of in vitro-transcribed (IVT) mRNA poly(A) tail by LC-HRAM-MS and BioPharma Finder 5.0 software Authors Application benefits Robert L. Ross1, Jenny England2, Rhonda • Confident identification and sequence confirmation of polyadenylated tails in synthetic…

Application Note 162 Determination of Nucleotides by Ion Chromatography with UV Absorbance Detection INTRODUCTION Nucleotides are negatively charged ionic molecules consisting of a nitrogenous organic base, a 5-carbon pentose sugar, and phosphoric acid. Figure 1 shows the five common bases…

Application Note Biopharma/Pharma Improved Metabolomic Analysis Using an Iron-Free Flow Path Comparing the Agilent 1290 Infinity II Bio LC System and Agilent 1290 Infinity II LC System for metabolomics ×105 ATP 4.5 4.0 Agilent 1290 Infinity II Bio LC Agilent…