Characterization of in vitro-transcribed (IVT) mRNA poly(A) tail by LC-HRAM-MS and BioPharma Finder 5.0 software

Application brief | 003060 Biopharma Accurate and consistent analysis of poly(A) tails of mRNA therapeutics on a UHPLC-HRAM-MS platform Application benefits Authors Hao Yang , Robert Ross , Min Du • Accurate and consistent measurement of poly(A) tail length and…

A simple and robust LC-MS method for determination of poly(A) tail length using the Orbitrap Exploris MS systems Hao Yang, Robert Ross, Keeley Murphy, Yi Zhang, Min Du, Thermo Fisher Scientific, San Jose, CA, USA INTRODUCTION The introduction of effective…

Biopharmaceuticals Analytical solutions for mRNA vaccines and therapeutics Table of contents mRNA vaccines and therapeutics mRNA characterization Lipid nanoparticle characterization Critical quality attributes of mRNA therapeutics Direct mRNA sequence confirmation LNP composition analysis by LC-CAD Optimize impurity analysis with ease…

Characterization of mRNA vaccine 5’ and 3’ end products using BioPharma Finder 5.0 Robert L Ross, Qian Qi, Keeley Murphy, Min Du, Thermo Fisher Scientific, Waltham, MA ABSTRACT Data Analysis 5’ Capping We sought the development of a Thermo Scientific™…