Building a Collision Cross Section Library of Pharmaceutical Drugs Using the Vion IMS QTof Platform: Verification of System Performance, Precision and Deviation of CCS Measurements

[ APPLICATION NOTE ] Small Molecule Ion Mobility Investigations into Cross-platform and Long-term Robustness of a CCS Metric Mike McCullagh, 1 Michelle Wood, 2 Nayan Mistry, 2 Severine Goscinny, 3 Petur Dalsgaard4 Waters Corporation, Wilmslow, UK; 2 Sciensano, Brussels, Belgium;…

[ APPLICATION NOTE ] Peptide Mapping with Higher Confidence: The Application Capability of IMS QTof Mass Spectrometry with Four-dimension (4D) Peak Detection (RT, m/z, intensity, and CCS values) Jing Fang, Ying Qing Yu, Min Du, and Weibin Chen Waters Corporation,…

[ APPLICATION NOTE ] Integrating Ion Mobility into Routine Drug Metabolite Identification Studies Using the Vion IMS QTof Mass Spectrometer Jayne Kirk, 1 Russell Mortishire-Smith, 1 and Mark Wrona 2 1 Waters Corporation, Wilmslow, UK 2 Waters Corporation, Milford, MA,…

INVESTIGATIONS INTO CROSS-PLATFORM AND LONG-TERM ROBUSTNESS OF A CCS METRIC Michael McCullagh1; Michelle Wood1; Nayan Mistry1; Martin Palmer1;Severine Goscinny2; David Douce1 and Petur Dalsgaard3 1 Waters Corporation, Wilmslow, United Kingdom; 2Sciensano, 14, rue Juliette Wytsman, Belgium; 3Department of Forensic Medicine,…