Improving SEC-MALS Data Quality with Ethylene Bridged Hybrid HPLC Size-Exclusion Columns

[ APPLICATION NOTEBOOK ] SIZE-EXCLUSION CHROMATOGRAPHY (SEC) OF PEPTIDES, PROTEINS, AND AAVs [ SIZE-EXCLUSION CHROMATOGRAPHY ] [ SIZE-EXCLUSION CHROMATOGRAPHY ] Introduction Gel-permeation chromatography (GPC), size-exclusion chromatography (SEC), and gel-filtration chromatography (GFC) are commonly used terms to describe a liquid chromatographic…

[ APPLICATION NOTE ] High Resolution and High Throughput Size-Exclusion Chromatography Separations of IgG Antibody Aggregates and Fragments on UHPLC and HPLC Systems with 2.5 µm BEH Particles Stephan M. Koza and Weibin Chen Waters Corporation, Milford, MA, USA APPLICATION…

[ APPLICATION NOTE ] Impact of LC System Dispersion on the Size-Exclusion Chromatography Analysis of Monoclonal IgG Antibody Aggregates and Fragments: Selecting the Optimal Column for Your Method Stephan M. Koza, Corey E. Reed, and Weibin Chen Waters Corporation, Milford,…

W H I T E PA P E R WP1618: Enhanced SEC-MALS analysis of therapeutic mAbs, biosimilars and AAVs with XBridge Premier columns Leo Liu, Ph.D., Waters | Wyatt Technology Summary SEC-MALS is widely used for the characterization of biopharmaceuticals.…