Assessing Repeatability of a Peptide Mapping Method Using the ACQUITY Arc Bio System

METHOD TRANSFER AND ROUTINE ANALYSIS OF PROTEIN AND PEPTIDE-BASED DRUG PRODUCTS USING A BIOCOMPATIBLE UHPLC SYSTEM Brooke M. Koshel, Robert Birdsall, Corey Reed, Stephan Koza, Zhimin Li, Paula Hong, Joe Fredette, and Scott Berger Waters Corporation INTRODUCTION Many of the…

[ APPLICATION NOTE ] Impact of Instrument and Detector Characteristics on Size Exclusion Chromatography Method Transfer Across Biocompatible UHPLC Systems Zhimin Li, Paula Hong, and Patricia R. McConville Waters Corporation, Milford, MA, USA APPLICATION BENEFITS ■■ ■■ INTRODUCTION Biocompatible system…

[ APPLICATION NOTEBOOK ] ACQUITY QDa Detector QC APPLICATIONS COMPENDIUM EDITION 2 Dear Colleague The 2013 introduction of the ACQUITY™ QDa™ Detector was a breakthrough in Chromatography and Mass Spectrometry integration. It was the fulfilment of a vision 20 years…

Application Note Migrating Peptide Mapping Methods from the Arc™ Premier System to the Alliance™ iS Bio System with Gradient SmartStart Technology and Intelligent Method Translator App (iMTA) Duanduan Han, Robert E. Birdsall, Karen Nyholm Waters Corporation Abstract The Alliance iS…