METHOD TRANSFER AND ROUTINE ANALYSIS OF PROTEIN AND PEPTIDE-BASED DRUG PRODUCTS USING A BIOCOMPATIBLE UHPLC SYSTEM

Application Note Method Transfer of Size-Exclusion and IonExchange Methods for Monoclonal Antibody Analysis from HPLC to the Arc Premier System Brooke M. Koshel, David Dao, Robert E. Birdsall, Ying Qing Yu Waters Corporation Abstract Transferring methods between internal laboratories and…

[ APPLICATION NOTEBOOK ] SIZE-EXCLUSION CHROMATOGRAPHY (SEC) OF PEPTIDES, PROTEINS, AND AAVs [ SIZE-EXCLUSION CHROMATOGRAPHY ] [ SIZE-EXCLUSION CHROMATOGRAPHY ] Introduction Gel-permeation chromatography (GPC), size-exclusion chromatography (SEC), and gel-filtration chromatography (GFC) are commonly used terms to describe a liquid chromatographic…

MAIN MENU TABLE OF CONTENTS [ APPLICATIONS NOTEBOOK ] BIOSEPARATIONS Tools, Techniques, and Insights into Biopharmaceutical Analysis INT RODUCTION Biopharmaceuticals have emerged as a dominant class due to their specificity and efficacy. T he production of biopharmaceuticals, however, is distinctly…

[ TECHNOLOGY BRIEF ] Charge Variant Analysis of Infliximab on the Alliance, ACQUITY Arc Bio, and ACQUITY UPLC H-Class Bio Liquid Chromatography Systems Using a Quaternary pH Gradient Corey E. Reed, Stephan M. Koza, and Weibin Chen, Waters Corporation, Milford,…