Improving the Recovery of Intact Antibodies from Reversed-Phase Separations Using a BioResolve RP mAb Polyphenyl Column

[ APPLICATION NOTE ] A Novel Phenyl Bonded Phase for Improved Reversed-Phase Separations of Proteins Jennifer M. Nguyen, Lavelay Kizekai, Dan Walsh, Jim Cook, and Matthew A. Lauber Waters Corporation, Milford, MA, USA APPLICATION BENEFITS ■■ ■■ Polyphenyl bonded phase…

UNIVERSITY OF COPENHAGEN FA C U LT Y O F S C I E N C E Enhancing Subunit-Level Profiling of mAbs and ADCs with MSQuality Difluoroacetic Acid Jennifer Nguyen1,2, Jacquelynn Smith3, Olga V. Friese3, Jason C. Rouse4, Daniel P.…

HIGH SENSITIVITY LC-MS PROFILING OF ANTIBODY DRUG CONJUGATES WITH DIFLUOROACETIC ACID ION PAIRING AND A HIGHCOVERAGE PHENYL-BONDED STATIONARY PHASE Jennifer Nguyen1,2, Jacquelynn Smith3, Olga V. Friese3, Jason C. Rouse4, Daniel P. Walsh1, and Matthew A. Lauber1 1 Waters Corporation, Milford,…

[ APPLICATION NOTE ] Protein Quantification in Formulation Buffer Using a BioResolve RP mAb Polyphenyl Column Hua Yang and Stephan Koza Waters Corporation, Milford, MA, USA APPLICATION BENEFITS ■■ ■■ ■■ INTRODUCTION Simple, fast separation of proteins Protein quantification is…