Application of a Mass Confirmation Workflow for Biotherapeutics Screening

Application Note Analysis of Cysteine-Conjugated Antibody Drug Conjugates (ADCs) Using a Native SEC LC-MS Workflow on the SYNAPT XS Henry Shion, Colette Quinn, Scott J. Berger, Ying Qing Yu Waters Corporation This is an Application Brief and does not contain…

Application Note Analysis of Antibody siRNA Conjugate Using BioAccord System Henry Shion, Catalin E. Doneanu, Ed Ha, Ying Qing Yu, Weibin Chen Waters Corporation, Angiex, Inc. Biopharmaceutical services at Waters Immerse Innovation and Research Center (www.waters.com/immerse <http://www.waters.com/immerse> ) aim to…

Application Note Advancing ADC Characterization: SECBased Native DAR and Drug Distribution Analysis Using Multi-Reflecting TOF-MS and INTACT Mass Application Jonathan Fox, Scott J Berger, Laetitia Denbigh, Sam Ippoliti Waters Corporation, United States Published on December 24, 2025 Abstract This technology…

[ TECHNOLOGY BRIEF ] Analysis of Antibody Drug Conjugates (ADCs) by Native Mass Spectrometry on the BioAccord System Henry Shion, Ying Qing Yu, and Weibin Chen Waters Corporation, Milford, MA, USA Drug-to-Antibody Ratio (DAR) determination of Lys and Cys conjugated…