Blowdown evaporation is a common sample preparation step used by analytical laboratories to dry down or concentrate their test samples. Dry gas is continuously blown onto the sample's surface, sometimes in conjunction with heat, to speed up the evaporation of excess solvent and further concentrate the sample prior to analytical techniques such as <a target="_blank" rel="noopener noreferrer" href="https://www.organomation.com/preparing-samples-for-gc-ms/ms-analysis">GC-MS</a> or <a target="_blank" rel="noopener noreferrer" href="https://www.organomation.com/preparing-samples-for-hplc-ms/ms-analysis">HPLC</a>. Nitrogen gas is most commonly used during <a target="_blank" rel="noopener noreferrer" href="https://www.youtube.com/watch?v=e9dbWmoWwSw">blowdown evaporation</a> as it provides the fastest evaporation rates, and is a proven safe drying media that poses minimal risk to the analysis.Dry nitrogen is considered an inert gas, which means that it is chemically inactive. Unlike compressed air that contains oxygen and water vapor that could react with the compounds in the test sample, pure, dry nitrogen will not deteriorate the sample in any way.High purity nitrogen is able to delay or prevent oxidation that could occur throughout the drying process. Depending on the solvents and solutes contained in the test sample, a chemical reaction could occur with a relatively small exposure to oxygen. Drying that sample down with compressed air which contains a fair amount of oxygen, will not only speed up the oxidation process, but also make your final analysis unreliable.What's even more important than keeping the samples safe, is keeping the lab technicians safe during the entire evaporation process. Since nitrogen is a non-reactive gas, it's also non-flammable and will not increase the risk of an chemical combustion. This is especially important when working with any flammable or otherwise reactive solvents such as carbon disulfide and diethyl ether.Not only is nitrogen gas the most reliable drying media, but it is also proven to have the fastest evaporation rate. Studies have shown that evaporation rate is dependent on the humidity of the atmosphere in which the samples are in. The more steps that can be taken to reduce the humidity, the faster the concentration rate will be. These same studies have shown that the most effective way to reduce the humidity is by purging the atmosphere with nitrogen, aka nitrogen blowdown evaporation.Faster concentration rates lead to a reduction in contamination and degradation risks by minimizing the amount of time the samples spend in the atmosphere. The use of nitrogen gas in blowdown evaporation provides labs with the most dependable samples to analyze in the quickest amount of time. It's a win-win.Another win is that nitrogen gas is a far more affordable alternative to other inert gasses such helium or argon. This is especially true with the use of a <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1902">nitrogen generator</a>, which can provide an endless supply of high-purity nitrogen for your laboratory. With minimal maintenance and virtually no waste, you can feel good knowing you're utilizing an <a target="_blank" rel="noopener noreferrer" href="https://blog.organomation.com/blog/are-nitrogen-generators-actually-more-environmentally-friendly">eco-friendly nitrogen generation solution</a>.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Organomation_NITRO_GEN_Nitrogen_Generator_1cce90a981.webp" alt="Organomation: Why Nitrogen is Ideal for Drying Samples: Organomation NITRO-GEN Nitrogen Generator." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Organomation_NITRO_GEN_Nitrogen_Generator_1cce90a981.webp 156w," sizes="100vw" width="1400" height="1400">Learn the most <a target="_blank" rel="noopener noreferrer" href="https://blog.organomation.com/blog/nitrogen-generation-options-for-laboratory-use">common nitrogen generation options for laboratory use</a>, and discover the solution that best fits your needs. For more information on nitrogen generators, check out this comprehensive guide: <a target="_blank" rel="noopener noreferrer" href="https://www.organomation.com/nitrogen-generators-everything-you-need-to-know">Nitrogen Generators: Everything You Need to Know</a>.

Why Nitrogen is Ideal for Drying Samples

Many industries rely on a nitrogen blowdown evaporator as a key step in processing their samples. These industries include environmental testing, agriculture, food and beverage, medicine, quality assurance, forensics, oil and grease, and many more. So, what exactly is it?A nitrogen blowdown evaporator is a key piece of lab equipment that is used to prepare samples for <a target="_blank" rel="noopener noreferrer" href="https://www.organomation.com/chromatography-sample-preparation-guide">chromatography</a>, <a target="_blank" rel="noopener noreferrer" href="https://www.organomation.com/mass-spectrometry-sample-preparation-guide">mass spectrometry</a> or other analysis by removing excess solvent. The process works by lowering the vapor pressure above the sample, allowing excess solvent to evaporate more quickly. This method of concentration is especially effective for small volume samples in volatile or semi-volatile organic solvents. The precision of nitrogen blowdown makes it a great choice for those who are looking to evaporate to complete dryness or stop at a specific endpoint.Compared to a heated sample, solvent molecules in a sample under ambient conditions are very low energy and therefore slow-moving. Due to this lack of speed, only some molecules can be vaporized and separated from the sample. Combined with the vapor pressure above the sample this causes many molecules to return, slowing down evaporation. This is where nitrogen blowdown evaporation is a useful tool. The evaporator works by applying a steady stream of nitrogen gas just above the surface of the sample, which gently pushes the vapor-saturated air out, preventing it from returning to the remaining liquid.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Organomation_What_is_Nitrogen_Blowdown_Evaporation_2_64a8e42723.jpg" alt="Organomation: What is Nitrogen Blowdown Evaporation?" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Organomation_What_is_Nitrogen_Blowdown_Evaporation_2_64a8e42723.jpg 245w," sizes="100vw" width="827" height="398">The nitrogen gas cools the sample slightly, which decreases the energy of the molecules and slows them down, diminishing their ability to vaporize. To speed the molecules back up, heat can be applied in the form of a water bath or dry block in order to reenergize the sample. The combination of nitrogen blowdown and heat quickly vaporizes the molecules, leaving a perfectly evaporated sample behind. If you are using a water bath, it should be set to a few degrees lower than the boiling point of your sample in order to achieve maximum concentration. On average, it takes only twenty-five minutes to safely concentrate a 10mL sample of methylene chloride using a nitrogen blowdown evaporator. This is compared to <a target="_blank" rel="noopener noreferrer" href="https://blog.organomation.com/blog/how-much-time-is-wasted-preparing-individual-sample-vials-infographic">evaporating samples by hand</a>, which can be a time-consuming process. For a few samples this can be justifiable, but for regular use, evaporation by hand is an inefficient process.Nitrogen blowdown is gentle on the sample and does not require any consumables, making it an affordable and safe choice. We offer three product lines of nitrogen blowdown evaporators – the most-popular N-EVAP and its counterparts, MULTIVAP, and MICROVAP. You can <a target="_blank" rel="noopener noreferrer" href="https://blog.organomation.com/blog/the-differences-between-organomations-blowdown-evaporators">learn more</a> about the differences between these products, and use our quick <a target="_blank" rel="noopener noreferrer" href="https://www.organomation.com/support/contact-help-support/sample-evaporator-product-finder">product finder</a> to figure out which one is the best fit for your needs.Nitrogen can be expensive to purchase and inconvenient to store. We are proud to make a lightweight and portable <a target="_blank" rel="noopener noreferrer" href="https://blog.organomation.com/blog/enhance-your-sample-preparation-with-a-nitrogen-gas-generator">nitrogen gas generator</a>, called the NITRO-GEN. It is the perfect solution for any laboratory looking for a low-cost solution to integrate with an existing clean air line. It also boasts a reduction in your carbon footprint, removing the emissions of transporting nitrogen cylinders to and from your lab.<blockquote>For more information on nitrogen blowdown evaporation or on any of our products, reach out to our team at <a href="mailto:sales@organomation.com">sales@organomation.com</a> or use our <a target="_blank" rel="noopener noreferrer" href="https://www.organomation.com/#hs-chat-open">live chat</a> during normal business hours.</blockquote>

What is Nitrogen Blowdown Evaporation?

<div><div><div><div><h3>How Does Your Monthly Nitrogen Gas Bill Compared to Other Labs?</h3>If your lab relies on nitrogen gas cylinders, you already know how quickly costs can add up. Between purchase prices, rental fees, delivery charges, and frequent refills, <a target="_blank" rel="noopener noreferrer" href="https://blog.organomation.com/blog/understanding-the-costs-of-renting-nitrogen-gas-cylinders-in-laboratories?hsLang=en">nitrogen cylinders can become a hidden financial drain</a> on your operations.But how do you know if you're paying a fair price—or if you're overspending compared to other labs? Our "Am I Overpaying on my Nitrogen Gas Cylinders?" tool helps you determine whether your current nitrogen supply costs are within an acceptable range or if you're paying too much.<h3>The Hidden Costs of Nitrogen Cylinders</h3>Nitrogen cylinders are a staple in many laboratories, but they come with several costly drawbacks:<h4>1. High Cylinder Costs</h4>The upfront cost of nitrogen cylinders can be significant, especially for labs that require multiple cylinders per month. Pricing varies depending on size and supplier, but the recurring need to purchase or replace cylinders creates an ongoing expense that can quickly add up. Unlike a fixed investment in a nitrogen generator, cylinder costs are a constant and unavoidable part of lab operations.<h4>2. Monthly Rental Fees</h4>Most gas suppliers charge a rental fee per cylinder, adding to the overall cost of maintaining a steady nitrogen supply. These fees might seem small at first, but when multiplied across multiple cylinders and months, they become a substantial recurring expense. Over time, these rental costs can easily surpass the price of investing in an in-house nitrogen generation system.<h4>3. Delivery &amp; Handling Expenses</h4>Delivery costs vary but can add hundreds of dollars per month to your nitrogen expenses, especially if you're receiving frequent shipments. Beyond costs, frequent deliveries create workflow disruptions and safety concerns due to cylinder handling and storage. Each delivery requires time, coordination, and often additional fees, making cylinders an inefficient option for labs that require a reliable nitrogen supply.<h4>4. Gas Waste</h4>Did you know that most nitrogen cylinders leave about 10% of their gas unused due to pressure limitations? That means you're paying for nitrogen you can’t even use. Additionally, each time a cylinder runs empty, there is downtime involved in switching to a new one, causing further inefficiencies in lab operations.<h4>5. Storage &amp; Safety Risks</h4>Cylinders require dedicated storage space and proper handling to prevent leaks, pressure hazards, and accidents. Many labs struggle with cylinder management, leading to compliance concerns and workflow inefficiencies. Storing multiple high-pressure cylinders also introduces potential safety risks, requiring strict adherence to safety protocols and regulatory standards.<h3>The Smarter Alternative: Switching to a Nitrogen Generator</h3>A nitrogen generator offers a cost-effective, on-demand solution for labs that need a steady nitrogen supply—without the ongoing expenses of cylinder rentals, refills, and deliveries. Here’s why more labs are making the switch:<ul><li>Eliminate Cylinder Costs – No more purchases, rentals, or refills.</li><li>Reduce Long-Term Expenses – A one-time investment with minimal maintenance.</li><li>On-Demand Supply – Generate high-purity nitrogen whenever you need it.</li><li>No More Deliveries – Say goodbye to disruptions and recurring delivery fees.</li><li>Increased Safety &amp; Efficiency – No handling of high-pressure cylinders.</li><li>Better Environmental Impact – <a target="_blank" rel="noopener noreferrer" href="https://blog.organomation.com/blog/are-nitrogen-generators-actually-more-environmentally-friendly?hsLang=en">Reduce carbon emissions</a> associated with cylinder deliveries and production.</li></ul>Many labs find that a <a target="_blank" rel="noopener noreferrer" href="https://www.organomation.com/would-a-nitrogen-generator-make-sample-preparation-more-affordable?hsLang=en">nitrogen generator pays for itself within a year</a>—especially if they use multiple cylinders per month. Beyond the financial savings, labs that <a target="_blank" rel="noopener noreferrer" href="https://blog.organomation.com/blog/why-nitrogen-generators-are-gaining-popularity?hsLang=en">switch to a nitrogen generator</a> experience greater efficiency, safety, and reliability in their daily operations.<blockquote>Learn More: <a target="_blank" rel="noopener noreferrer" href="https://www.organomation.com/nitrogen-generators-for-sample-preparation-everything-you-need-to-know?hsLang=en">Nitrogen Generators for Sample Preparation: Everything you need to know</a>Watch Our Webinar: <a target="_blank" rel="noopener noreferrer" href="https://explore.organomation.com/the-case-for-nitrogen-generation-in-your-lab?hsLang=en">Improving Laboratory Workflows with Nitrogen Generation</a></blockquote><h3>Find Out If You’re Overpaying</h3>Not sure if switching to a nitrogen generator makes sense for your lab? Use our "Am I Overpaying on My Nitrogen Gas Cylinders?" tool to compare your costs against industry benchmarks. Simply answer a few quick questions, and we’ll help you determine whether it’s time to make the switch.</div></div></div></div>

Am I Paying Too Much for my Nitrogen Gas Cylinders?

In laboratories focused on sample preparation, especially in workflows involving <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/article/5392">nitrogen blowdown evaporation</a>, the need for a consistent, high-flow nitrogen supply is non-negotiable. Traditionally, many labs have relied on gas cylinders to meet this demand, but with rising operational costs and safety concerns, <a target="_blank" rel="noopener noreferrer" href="https://www.organomation.com/nitrogen-generators-for-sample-preparation-everything-you-need-to-know">on-site nitrogen generators</a> have become a more efficient and sustainable alternative.This post compares three leading <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products?category=97&amp;manufacturerItems=540">nitrogen generators for sample prep applications</a>:<ul><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1901">Organomation's NITRO-GEN+</a></li><li>Peak Scientific's Genius XE 35</li><li>Parker's NitroFlow Lab</li></ul>Each unit supports nitrogen evaporation techniques, but there are key differences in cost, performance, and practicality that may influence your decision.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Organomation_Choosing_a_Nitrogen_Generator_for_Sample_Preparation_Organomation_vs_Peak_vs_Parker_0cf23817b3.jpg" alt="Organomation: Choosing a Nitrogen Generator for Sample Preparation - Organomation vs. Peak vs. Parker" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Organomation_Choosing_a_Nitrogen_Generator_for_Sample_Preparation_Organomation_vs_Peak_vs_Parker_0cf23817b3.jpg 245w," sizes="100vw" width="1500" height="800"><h4>Cost Efficiency</h4>One of the primary considerations for any lab is cost. While all three models include built-in compressors, removing the need for external air sources, the NITRO-GEN+ is designed to offer maximum value. It provides competitive performance at a lower initial investment, making it ideal for labs seeking to stretch their budget without compromising reliability.In contrast, the Peak Genius XE 35 and Parker NitroFlow Lab are both positioned as premium units with added features that may not be necessary for routine sample preparation tasks.<blockquote>Be sure to <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/N2_Generator_Comparison_PDF_1_2b9670e2f6.pdf">download the full nitrogen generator comparison PDF </a>to view actual pricing.</blockquote><h4>Performance in Evaporation Workflows</h4>Sample prep workflows often require high flow rates to support multiple nitrogen blowdown evaporators or multitasking across instruments. Here's how the three units stack up:<h5>Organomation NITRO-GEN+</h5><ul><li>Flow rate: up to 35 L/min</li><li>Max pressure: 116 psi (8 bar)</li><li>Purity: up to 99%</li></ul><h5>Peak Genius XE 35</h5><ul><li>Flow rate: up to 35 L/min</li><li>Max pressure: 116 psi (8 bar)</li><li>Purity: up to 99.5%</li></ul><h5>Parker NitroFlow Lab</h5><ul><li>Flow rate: up to 32 L/min</li><li>Max pressure: 116 psi (8 bar)</li><li>Purity: up to 99.5%</li></ul>All three units meet the pressure and flow demands for evaporation, but the NITRO-GEN+’s 35 L/min output ensures compatibility with multiple evaporators or high-volume workflows.The slightly lower purity (99%) is more than sufficient for nitrogen blowdown applications, where purity above 98% is typically acceptable. Higher-purity models, like those from Peak and Parker, may be better suited for ultra-sensitive analytical methods, but are not essential for evaporation.<h4>Physical Specifications and Usability</h4><h5>Organomation NITRO-GEN+</h5><ul><li>Compressor: Included</li><li>Touch screen: No</li><li>Noise level: 55 dBA</li><li>Dimensions: 19 × 33 × 25 in.</li><li>Weight: 198 lbs.</li></ul><h5>Peak Genius XE 35</h5><ul><li>Compressor: Included</li><li>Touch screen: Yes</li><li>Noise level: &lt;56 dBA</li><li>Dimensions: 25 × 22.5 × 28 in.</li><li>Weight: 202 lbs.</li></ul><h5>Parker NitroFlow Lab</h5><ul><li>Compressor: Included</li><li>Touch screen: Yes</li><li>Noise level: &lt;58 dBA</li><li>Dimensions: 28 × 12 × 35 in.</li><li>Weight: 204 lbs.</li></ul>All three models are self-contained and easy to install. The NITRO-GEN+ has a slightly smaller footprint and quieter operation, but the differences are marginal.Labs that prioritize a modern user interface may prefer the touch screens available on the Peak and Parker models. However, the NITRO-GEN+’s straightforward display offers simplicity and reliability without the added complexity.<h4>Warranty and Support</h4><h5>Organomation NITRO-GEN+</h5><ul><li>System warranty: 2 years or 8,000 hours</li><li>Compressor: Included in system warranty</li></ul><h5>Peak Genius XE 35</h5><ul><li>System warranty: 2 years</li><li>Compressor: Included in system warranty</li></ul><h5>Parker NitroFlow Lab</h5><ul><li>System warranty: 1 year</li><li>Compressor: 2 years or 8,000 hours</li></ul>Warranty coverage is an important consideration, especially for high-throughput labs. Organomation’s 2-year/8,000-hour warranty on the NITRO-GEN+ provides peace of mind, aligning with what most labs expect for mission-critical equipment.<h4>Conclusion</h4>If your lab relies on nitrogen for evaporation, concentration, or solvent removal, the Organomation NITRO-GEN+ offers an ideal balance of performance, reliability, and cost-effectiveness. While the Peak and Parker units offer slightly higher purity and interface enhancements, these features may not be necessary for most sample preparation workflows.For labs looking to increase efficiency, reduce gas cylinder costs, and maintain reliable evaporation performance, the NITRO-GEN+ stands out as a smart, practical investment.Find out which generator is best for your lab by utilizing our <a target="_blank" rel="noopener noreferrer" href="https://www.organomation.com/nitrogen-generator-product-finder">nitrogen generator product finder.</a> And to see how much you could save by switching to a nitrogen generator, try our <a target="_blank" rel="noopener noreferrer" href="https://www.organomation.com/how-much-could-i-save-switching-to-a-nitrogen-generator">generator savings calculator</a>!

Choosing a Nitrogen Generator for Sample Preparation: Organomation vs. Peak vs. Parker

<h4>What is a laboratory nitrogen generator and when is one used?</h4>A laboratory nitrogen generator is a machine that is able to separate nitrogen molecules from the air around it by using a compressed air source. By removing the vast majority of oxygen molecules and other impurities from an air source, these machines are able to produce high purity or ultra-high purity nitrogen gas needed to run a variety of different laboratory applications and instruments.There are many applications that require a lab to use a nitrogen gas generator, with LC-MS, GC, ICP, ELSD, and sample preparation/blowdown evaporation being the most common. Each application will have specific nitrogen requirements (flow rate, purity level, etc.) which will determine the exact type of N2 generator needed by the lab.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Organomation_Gas_Flow_and_Purity_Requirements_by_Application_e018a3a5df.jpg" alt="Organomation: Gas Flow and Purity Requirements by Application" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Organomation_Gas_Flow_and_Purity_Requirements_by_Application_e018a3a5df.jpg 245w," sizes="100vw" width="1167" height="461">N2 gas generators aren’t the only way labs are able to obtain nitrogen. Let’s get into some other common sources, and discuss when they may be a better fit.<h4>Common ways labs obtain nitrogen</h4>Although nitrogen generators are a must-have for many laboratories, there are some instances where they just don’t make sense. Some labs may have a nitrogen consumption rate that is just too high for a generator to meet. On the other hand, some may require such a low amount of gas that the purchase of a generator can’t be justified.<h4>So what are the common nitrogen gas sources for labs and who should be using each?</h4><h5>1. Nitrogen Tanks, Cylinders, or Dewars</h5>Ordering nitrogen gas from a third party vendor and having it delivered to your facility in tanks, cylinders, or Dewars is a great option for labs who have a very low or sporadic need for nitrogen. It’s a convenient way to get a small amount of N2 gas which may only be needed for a single project, without committing to the purchase of a new piece of equipment.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Organomation_nitrogen_7_cb5c6ba92d.jpg" alt="Organomation: Nitrogen Tanks, Cylinders, or Dewars" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Organomation_nitrogen_7_cb5c6ba92d.jpg 234w," sizes="100vw" width="438" height="292"><h5>2. Built-In Nitrogen Source</h5>Some large analytical or manufacturing companies have full nitrogen systems installed directly in their building which are able to supply gas to an entire lab or labs, depending on the size. This allows lab techs to have a constant supply of N2 gas piped directly to their fume hood or workstation. Due to the cost and space requirements, this is only a worthwhile investment for large laboratories with very high nitrogen consumption requirements.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Organomation_nitrogen_6_07dce4d97c.jpg" alt="Organomation: Built-In Nitrogen Source" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Organomation_nitrogen_6_07dce4d97c.jpg 229w," sizes="100vw" width="450" height="306"><h5>3. Nitrogen Generator</h5>Investing in a nitrogen gas generator is an ideal choice for labs who fall in the middle of options 1 and 2. If your application requires N2 on a regular basis, but doesn’t necessitate a building-wide gas source, a generator is the perfect accommodation. Most are completely plug-and-play, meaning once it’s set up, you can simply turn it on or off as needed, without any reconfiguration.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Organomation_nitrogen_5_70f9f8c6ac.jpg" alt="Organomation: Nitrogen Generator" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Organomation_nitrogen_5_70f9f8c6ac.jpg 231w," sizes="100vw" width="460" height="311"><h4>Which nitrogen generator technology is right for me?</h4>There are two common types of N2 generators, differentiated by the way they separate nitrogen molecules from the air. There are membrane-based generators and PSA generators.<h5>1. Membrane-Based</h5>The technology behind membrane-based nitrogen generators is…you guessed it…a membrane. This type of generator contains a series of narrow, semi-permeable fibers located in a porous membrane. As compressed air is passed through, some gas molecules such as oxygen, carbon dioxide and water vapor are able to permeate the fibers quite easily and are vented off, while nitrogen molecules pass through much slower. This results in a high purity nitrogen stream (95-99% purity) from the membrane outlet.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Organomation_nitrogen_4_015d9a533e.jpg" alt="Organomation: NITRO-GEN" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Organomation_nitrogen_4_015d9a533e.jpg 98w," sizes="100vw" width="221" height="351"><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1902">Organomation’s NITRO-GEN</a> is a popular membrane-based N2 generator for sample preparation that is used by analytical laboratories worldwide. Producing up to 20 L/min at up to 99% purity, this lightweight generator is suitable for those using blowdown evaporation for solvent concentration. Find out how the NITRO-GEN supplies high purity nitrogen for a sample concentrator.<h5>2. PSA (Pressure Swing Adsorption) Technology</h5>PSA generators work by using two columns of tightly packed material called Carbon Molecular Sieve (CMS). Compressed air will pass through one CMS column, which will adsorb all oxygen, water vapor and other molecules, while allowing nitrogen to pass through and be stored in an accumulation tank. Once one sieve becomes saturated, compressed air will be diverted to the second CMS column, allowing the first one to depressurize, releasing all adsorbed impurities through an outlet. This process repeats over and over, leaving behind N2 gas with a 98-99.999% purity.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Organomation_nitrogen_3_2cea8f24ba.jpg" alt="Organomation: NITRO-GEN+ " srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Organomation_nitrogen_3_2cea8f24ba.jpg 156w," sizes="100vw" width="600" height="600">As this technology tends to produce a slightly higher purity and flow rate than with membranes, PSA generators are a great choice for both sample preparation and LC-MS applications. The <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1901">NITRO-GEN+</a> is an affordable PSA generation solution that is able to produce up to 35 L/min, meeting all your sample prep and analytical needs. Find out how the NITRO-GEN+ can be your laboratory’s all-in-one nitrogen generation solution.<h4>The true cost of tank-based nitrogen solutions</h4>Although seen as the popular and “traditional” nitrogen generation solution by many, the process of purchasing N2 tanks is quite pricey, especially for those consuming gas on a weekly or daily basis. There are many associated costs with tank-based solutions including the cost of the actual nitrogen, tank rentals, and required delivery. Let’s take a look at how much one analytical lab could be spending on tanks in just one year.<blockquote>** This example uses estimated pricing. Your actual costs may vary.</blockquote>A typical nitrogen tank costs around $50. It’s also common for vendors to charge a monthly rental fee, which is often around $20 each month, per individual cylinder. On top of that, you’ll be charged for delivery – for this example, let’s say the lab orders their tanks locally and it only costs them $25 per delivery.Now, let’s estimate the nitrogen consumption for this particular lab. Let’s say they need 30 L/min of nitrogen for 4 hours a day, 5 days a week. That equals 36,000 liters of nitrogen per week, or about 5 cylinders. Over the course of a whole year, that’s nearing 2 million liters and over 250 nitrogen cylinders.In just one year, this lab would be spending over $18,000 in nitrogen tanks alone! For most, this just isn’t feasible.<h4>Is it cheaper to generate my own nitrogen?</h4>Acquiring a generator and producing your own nitrogen is a sure way to cut back on these extensive costs. Laboratory generators that are able to produce moderate flow rates and purity levels can range anywhere from $5,000 to $40,000. This one-time payment plus any required maintenance are the only things you have to take care of. No more worrying about rental costs, delivery costs, or wondering why the price of tanks has suddenly increased.Depending on a lab’s nitrogen consumption levels, the payback period on a N2 generator could be as little as 1-3 years.Determine how long it would take your lab to pay off a generator by using this simple <a target="_blank" rel="noopener noreferrer" href="https://www.organomation.com/would-a-nitrogen-generator-make-sample-preparation-more-affordable">nitrogen generator payback period calculator,</a> and see how much you could be saving.<h4>All the headaches you can save by adding on-site nitrogen generation</h4>Now that you’ve seen how much money a generator can save you compared to tanks, let’s dive deeper into all the headaches nitrogen generators can save you to determine if generating nitrogen in your lab is worthwhile.<h5>1. No need to purchase, store, or handle nitrogen cylinders</h5>Not only are tank-based nitrogen solutions expensive, they are also quite time-consuming and labor-intensive. Having to dedicate a closet or a corner of the lab to store extra tanks or remembering to order more when you’re running low are just minor inconveniences. Not to mention, high-pressure tanks can be a danger to those handling them.<h5>2. Never run out of nitrogen again</h5>With tanks, you always have to make sure you have enough for the day or week ahead. Running out of nitrogen unexpectedly can cause major hiccups in your workflow, and can even ruin the analysis/test you’re currently working on. With a nitrogen generator, you’ll always have a steady stream of high purity nitrogen available when you need it.<h5>3. Never pause your operation to replace N2 tanks</h5>Let’s say you’re in the middle of concentrating down some analytical samples using a nitrogen dryer, and your nitrogen tank has just run out. You’re forced to stop the evaporation process, disconnect the empty tank, move it aside, bring in a new tank, recalibrate it, and hook it up to the evaporator. All the while your samples are sitting in the open air with the risk of oxidizing or otherwise becoming contaminated. With the constant gas supply a N2 generator provides, you’ll never have to worry about this happening.<h5>4. Reduce waste and be more eco-friendly</h5>Utilizing a laboratory generator can help reduce your carbon footprint by eliminating the need to participate in tank exchanges and having nitrogen cylinders shipped to and from your laboratory. Since you’re generating nitrogen from the air around you, you’ll never require a refill or replacement.<h4>Why nitrogen is ideal for drying samples</h4>Labs using nitrogen blowdown evaporation, a common sample preparation step before analysis, are major drivers of the nitrogen generation market. Have you ever wondered why nitrogen is used to dry down excess solvent? It’s actually quite simple.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Organomation_nitrogen_2_6c56104216.jpg" alt="Organomation: nitrogen is ideal for drying samples" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Organomation_nitrogen_2_6c56104216.jpg 236w," sizes="100vw" width="866" height="572"><h5>1. It has the fastest evaporation rate.</h5>Studies have proven that nitrogen gas yields the fastest evaporation rates compared to other inert gasses. Evaporation rate is dependent on the humidity of the atmosphere. So what’s the most effective way to reduce humidity levels? – by purging the atmosphere with nitrogen, aka nitrogen blowdown evaporation.<h5>2. It poses minimal risks to samples &amp; lab techs.</h5>Dry nitrogen is considered an inert gas, meaning it is chemically inactive. Unlike compressed air that contains high levels of oxygen and other impurities, dry nitrogen will not deteriorate your samples in any way during the evaporation process. N2 is also non-flammable, meaning it will not increase the risk of a chemical combustion, which is especially important when working with other flammable or reactive solvents.<h5>3. It's affordable.</h5>Nitrogen gas is far more affordable than other inert gasses such as helium or argon. And as you’ve learned thus far, this is especially true when using a nitrogen generator which can provide an endless supply of high purity N2.<h4>Installing a nitrogen generation system for sample preparation</h4>Nitrogen generators have been used and trusted for sample concentration for years, specifically in conjunction with the TurboVap, <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products?manufacturerItems=540&amp;search=N-EVAP">N-EVAP,</a> and RapidVap. Once you've narrowed down your options, it's important to also take a look at the key considerations for installing a generator in your lab.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Organomation_nitrogen_e00163c1b6.jpg" alt="Organomation: Baylor University - Robbins College of Health and Human Services Supplying multiple nitrogen dryers with one generator" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Organomation_nitrogen_e00163c1b6.jpg 209w," sizes="100vw" width="2000" height="1500">To conclude, let's take a look at some real-life examples of laboratories who have integrated a nitrogen generator into their sample preparation workflow to see just how impactful it can be.<blockquote>If you have any questions or would like assistance with your nitrogen generator journey, please reach out to sales@organomation.com or call our team at 978-838-7300.</blockquote>

Nitrogen Generators for Sample Preparation: Everything You Need To Know

Nitrogen gas is the unsung hero of modern laboratory operations, quietly enabling countless analytical procedures, protecting sensitive equipment, and maintaining the inert atmospheres essential for accurate scientific work. Yet despite its critical importance, many laboratory managers struggle with <a target="_blank" rel="noopener noreferrer" href="https://www.organomation.com/how-much-could-i-save-switching-to-a-nitrogen-generator">selecting the optimal nitrogen supply</a> method for their facility's unique needs.The choice between traditional cylinder delivery, bulk liquid supply, or on-site generation can significantly impact your laboratory's operational efficiency, costs, and research capabilities. This blog explores each supply method in detail, helping you make an informed decision that aligns with your laboratory's requirements and long-term goals.<h4>Understanding Laboratory Nitrogen Demand</h4>Before diving into supply methods, it's essential to understand why laboratories consume such substantial quantities of nitrogen. Modern analytical instruments are increasingly nitrogen-hungry, with applications ranging from liquid chromatography-mass spectrometry (LC-MS) systems that require continuous gas flow to maintain optimal performance, to nuclear magnetic resonance (NMR) spectroscopy equipment that depends on nitrogen for cooling and atmospheric control.Beyond instrumentation, nitrogen serves critical roles in sample preparation, where it <a target="_blank" rel="noopener noreferrer" href="https://blog.organomation.com/blog/lipidomics-workstation-for-oxidation-free-reactions-and-solvent-evaporation">prevents oxidation during reactions</a>, and in maintaining inert atmospheres within gloveboxes used for handling air-sensitive materials. The gas also protects valuable cell cultures in incubators and ensures proper atmospheric conditions in fume hoods, making it indispensable across virtually every laboratory discipline.While Organomation sample concentrators are more conservative when it comes to nitrogen consumption, nitrogen is the driving force in <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/article/5392">blowdown evaporation</a>.<h4>Traditional Cylinder Supply: The Familiar Choice</h4><a target="_blank" rel="noopener noreferrer" href="https://blog.organomation.com/blog/how-gas-cylinders-can-disrupt-gas-chromatography-sample-preparation">Cylinders of nitrogen gas</a> have long been the default choice for laboratory nitrogen supply, and for good reason. These high-pressure vessels offer immediate availability, require minimal infrastructure investment, and provide flexibility for laboratories with variable or seasonal nitrogen demands.<h5>The Cylinder Advantage</h5>Cylinder supply excels in situations where nitrogen usage is intermittent or unpredictable. Small research facilities, teaching laboratories, and specialized testing facilities often find cylinders perfectly adequate for their needs. The system requires no upfront capital investment in generation equipment, and maintenance responsibilities rest entirely with the gas supplier.<h5>Hidden Costs and Operational Challenges</h5>However, the apparent simplicity of cylinder supply masks several significant drawbacks. The per-unit cost of nitrogen from cylinders is substantially higher than other supply methods, particularly when factoring in delivery charges, cylinder rental fees, and administrative overhead. More critically, cylinders introduce operational risks that can disrupt research workflows.Running out of nitrogen mid-analysis can invalidate hours of work and potentially damage sensitive samples. The physical handling of heavy cylinders presents safety risks, while the need for regular ordering and delivery coordination creates administrative burden. Additionally, cylinder storage requires dedicated space and proper ventilation, reducing available laboratory real estate.<h4>Bulk Liquid Supply: Scaling Up Efficiency</h4>For laboratories with substantial nitrogen consumption, bulk liquid supply offers a compelling middle ground between cylinders and on-site generation. This approach involves storing nitrogen in liquid form in large tanks, then vaporizing it to gas as needed and distributing it throughout the facility via permanent piping. While liquid nitrogen dewars can be placed outside of a building, they are also stored in warehouse storage or dedicated rooms as well.<h5>Economic and Operational Benefits</h5>Bulk liquid supply dramatically reduces the per-unit cost of nitrogen compared to cylinders, making it economically attractive for high-volume users. The system eliminates the constant cycle of cylinder changes, reducing both labor costs and operational disruptions. Large storage capacity means fewer deliveries and greater supply security.<h5>Infrastructure Requirements and Limitations</h5>The transition to bulk liquid supply requires significant infrastructure investment, including outdoor storage tanks, vaporization equipment, and internal distribution piping. Facilities must have adequate outdoor space for tank placement and comply with safety regulations governing cryogenic liquid storage.<h4>On-Site Nitrogen Generation: The Modern Solution</h4>On-site nitrogen generators represent the cutting edge of laboratory gas supply, offering unprecedented control, cost-effectiveness, and operational reliability. These systems produce nitrogen gas directly from ambient air, eliminating external dependencies while providing unlimited supply capacity.<h5>Pressure Swing Adsorption Technology</h5>Pressure Swing Adsorption (PSA) generators utilize specialized adsorbent materials, typically carbon molecular sieves, to separate nitrogen from compressed air. The process operates through cyclical pressurization and depressurization, with adsorbent beds alternately capturing oxygen and other gases while allowing nitrogen to pass through.PSA technology excels in applications requiring high purity nitrogen, capable of producing gas with purity levels up to 99.999%. This makes <a target="_blank" rel="noopener noreferrer" href="https://blog.organomation.com/blog/what-pressure-swing-adsorption-psa-technology">PSA nitrogen generators</a> ideal for critical analytical applications, pharmaceutical manufacturing, and research requiring ultra-pure atmospheres. The technology offers excellent energy efficiency and can be precisely tuned to match specific purity requirements.<h5>Membrane Separation Technology</h5><a target="_blank" rel="noopener noreferrer" href="https://blog.organomation.com/blog/how-do-membrane-nitrogen-generators-work">Membrane nitrogen generators </a>employ semi-permeable hollow fiber membranes that exploit the different permeation rates of atmospheric gases. Oxygen, water vapor, and carbon dioxide pass through the membrane walls more rapidly than nitrogen, effectively concentrating nitrogen in the non-permeate stream.While membrane technology typically produces nitrogen with purity levels up to 99.5%, it offers several advantages including lower maintenance requirements, simpler operation, and excellent reliability. Membrane generators are particularly well-suited for applications where ultra-high purity isn't critical, such as general laboratory atmospheres, packaging applications, and routine analytical work.<h4>How Should Nitrogen be Supplied to your Lab?</h4>Selecting the right nitrogen supply method represents a strategic decision that will impact your laboratory's operations for years to come. While the initial analysis may seem complex, the long-term benefits of choosing the optimal solution far outweigh the effort required for proper evaluation.Consider engaging with multiple suppliers to obtain detailed proposals and cost analyses based on your specific requirements. Many suppliers offer trial periods or pilot programs that allow hands-on evaluation of different technologies before making final commitments.Remember that the lowest initial cost rarely represents the best long-term value. Focus on total cost of ownership, operational reliability, and alignment with your laboratory's research mission when making your final decision.The investment in proper nitrogen supply infrastructure pays dividends in improved research capabilities, reduced operational stress, and enhanced scientific productivity. Choose wisely, and your laboratory will benefit from reliable, cost-effective nitrogen supply for years to come.Luckily, Organomation offers several tools to help make the analysis and task of product selection easier:<ul><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/article/5518">Is renting nitrogen gas cylinders too expensive?</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://www.organomation.com/how-much-could-i-save-switching-to-a-nitrogen-generator">Will a nitrogen generator save me money?</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://www.organomation.com/nitrogen-generator-product-finder">Which nitrogen generator is right for me?</a></li></ul>

How Are Laboratories Supplied with Nitrogen?

If you have been following my <a target="_blank" rel="noopener noreferrer" href="https://concentratingonchromatography.com/">Concentrating on Chromatography podcast</a>, you know that I am constantly searching for the cutting edge of separation science. After years of interviewing the brightest minds in the field, it has become clear to me that the <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/companies/218">Multidimensional Chromatography Workshop (MDCW)</a> is undeniably the best up-and-coming event in our industry.While I was unfortunately traveling in Asia during the most recent session, I was able to catch every detail thanks to the incredible work of <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/companies/1">LabRulez</a>. A huge thank you to Ivo Novotný and the LabRulez team for providing <a target="_blank" rel="noopener noreferrer" href="https://www.youtube.com/playlist?list=PLg-M6fM-05MrGrDggkl_UKzzcHPWPmssh">Open Access video presentations</a> of the event. Their <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/">portal </a>is an invaluable resource for anyone who needs to find technical information quickly and efficiently.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Organomation_MDCW_The_Premier_Up_and_Coming_Event_in_Chromatography_2_65b378bf01.jpg" alt="Organomation: MDCW: The Premier Up-and-Coming Event in Chromatography" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Organomation_MDCW_The_Premier_Up_and_Coming_Event_in_Chromatography_2_65b378bf01.jpg 245w," sizes="100vw" width="1044" height="455"><h3>The Minds Behind the Magic</h3>I have had the privilege of featuring the core organizers of MDCW on my podcast, including <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/articles?search=Katelynn+Perrault+Uptmor">Katelynn Perrault Uptmor</a>, <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/articles?search=Dwight+Stoll">Dwight Stoll</a>, and <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/articles?search=Petr+Vozka">Petr Vozka</a>. Their dedication to creating a space where forensic chemistry, environmental analysis, and metabolomics intersect is what makes this workshop so unique. The event is a perfect showcase for how multidimensional techniques—like GC×GC and 2D-LC—are essential for tackling the world's most complex samples.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Organomation_MDCW_The_Premier_Up_and_Coming_Event_in_Chromatography_265c9ec21e.jpg" alt="Organomation: MDCW: The Premier Up-and-Coming Event in Chromatography" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Organomation_MDCW_The_Premier_Up_and_Coming_Event_in_Chromatography_265c9ec21e.jpg 245w," sizes="100vw" width="792" height="230"><h3>Where Sample Prep Meets High-Resolution Analysis</h3>As we often discuss at Organomation, even the most advanced chromatographic systems depend on meticulous sample preparation. Two presentations highlighted in the LabRulez playlist perfectly illustrate the critical role of <a target="_blank" rel="noopener noreferrer" href="https://www.organomation.com/what-is-solvent-evaporation">solvent evaporation</a> and <a target="_blank" rel="noopener noreferrer" href="https://www.organomation.com/what-is-sample-concentration">sample concentration</a>.<h3>Chemical Fingerprints: Emma Macturk’s Quest for Hidden Data</h3><a target="_blank" rel="noopener noreferrer" href="https://www.youtube.com/watch?v=1W5197sp6IY">Emma Macturk</a>, working in Dr. Katelynn Perrault Uptmor’s lab, is redefining how we look at one of the oldest forms of forensic evidence: the fingerprint. While traditional forensics relies on the physical patterns of ridges and whorls, these are often incomplete or smudged in real-world scenarios. Emma’s research shifts the focus to the chemical residue left behind, which can provide vital "class characteristics" like the biological sex and relative age of a suspect.Her optimized workflow is a masterclass in handling complex biological matrices. Using a cotton swab to extract residue from surfaces, the samples are centrifuged and then "<a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/article/5392">blown down</a>" (a critical concentration step for any trace analysis) before <a target="_blank" rel="noopener noreferrer" href="https://www.organomation.com/what-is-reconstitution">being reconstituted for GC×GC-TOFMS</a>.What makes her work truly fascinating—and highly relevant for our readers at Organomation—is the discovery of anthropogenic compounds. Emma identified UVB blockers like octocrylene and various moisturizers hidden within the natural sterols and fatty acids of the skin. The power of multidimensional chromatography allows forensic scientists to resolve these external "lifestyle" markers from endogenous skin compounds, potentially providing a much more detailed profile of a suspect than a physical print ever could.<h3>The "Green" Revolution: Grace Saunders and the Future of Ballistics</h3><a target="_blank" rel="noopener noreferrer" href="https://www.youtube.com/watch?v=ClD4fjZMNtA">Grace Saunders</a> addressed a looming crisis in forensic ballistics: the shift toward "green ammunition." For decades, the gold standard for detecting gunshot residue (GSR) has been SEM-EDS, which looks for heavy metals like lead, barium, and antimony. However, modern environmental and health standards are leading manufacturers to omit these metals. This means that traditional standards are failing to identify GSR in cases involving green rounds.Grace’s research proposes a dual-pronged approach, using GC×GC to target Organic Gunshot Residue (OGSR). Her liquid extraction protocol is meticulous: samples are extracted in methanol, "<a target="_blank" rel="noopener noreferrer" href="https://www.organomation.com/what-is-evaporation-to-dryness">evaporated to dryness under nitrogen</a>," and then reconstituted. This ensures that volatile and semi-volatile nitroaromatic compounds, such as nitroglycerin and diphenylamine, are concentrated enough for detection.By optimizing parameters like the modulation period (2.5 seconds) and switching to hydrogen carrier gas, Grace was able to resolve these critical markers from the complex background "noise" of human skin. Her work isn't just about better chemistry; it’s about legal survival. As she noted, forensic methods must meet Federal Rule 702 for admissibility in court. Without the organic profiling Grace is developing, evidence from a "green" firearm discharge might never make it past a judge.<h3>The Future of Chromatography</h3>The workshop also featured brilliant presenters like <a target="_blank" rel="noopener noreferrer" href="https://www.youtube.com/watch?v=YJm_JwHbArE">Ryland Giebelhaus</a>, whose work on the metabolomics of cannabis exposure during pregnancy shows the real-world impact of these technologies.The MDCW isn't just another conference; it is a community-driven powerhouse that bridges the gap between proof-of-concept and field-ready applications. Whether you are looking for advanced data reduction strategies or the latest in high-resolution mass spectrometry, this is the event to watch.<blockquote>If you missed it this year like I did, I highly recommend visiting the <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?search=MDCW">LabRulez portal</a> to see the full breadth of research presented!</blockquote>

MDCW: The Premier Up-and-Coming Event in Chromatography

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Organomation, founded in 1959, designs and manufactures high-quality nitrogen evaporators and extraction systems. Known for innovation and durability, their lab instruments are used globally for efficient sample preparation with strong customer support.

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