In recent years, the spotlight on the safety of baby food has intensified, driven by growing concerns about toxic heavy metals like arsenic, cadmium, lead, and mercury. These elements, even in low concentrations, pose significant health risks to infants and toddlers, whose developing bodies are particularly vulnerable. As regulatory standards tighten, advanced analytical techniques such as inductively coupled plasma mass spectrometry (ICP-MS) have emerged as crucial tools in ensuring baby food meets stringent safety and nutritional benchmarks.<h4>The importance of monitoring heavy metals in baby food</h4>Heavy metals can make their way into baby food through environmental contamination, agricultural practices, or industrial processes. For instance:<ul><li>Lead can leach from soil into crops.</li><li>Arsenic is often present in rice and rice-based products due to its natural occurrence in water and soil.</li><li>Mercury can accumulate in fish and seafood.</li><li>Cadmium is introduced via contaminated soil or fertilizers.</li></ul>Even trace amounts of these metals can lead to neurological damage, developmental delays, and other long-term health issues. Regulatory bodies like the FDA and the European Union have established maximum permissible levels for these toxic elements. For example, the Baby Food Safety Act of 2021 in the U.S. mandates maximum limits such as 10 µg/kg for inorganic arsenic and 5 µg/kg for lead in baby food products.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_Ensuring_Baby_Food_Safety_Tackling_Toxic_Metals_with_Advanced_Technology_275fac6f68.jpg" alt="Thermo Fisher Scientific: Ensuring Baby Food Safety - Tackling Toxic Metals with Advanced Technology" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_Ensuring_Baby_Food_Safety_Tackling_Toxic_Metals_with_Advanced_Technology_275fac6f68.jpg 239w," sizes="100vw" width="1536" height="1006"><h4>The role of ICP-MS in baby food safety</h4>To comply with these regulations, manufacturers require robust analytical methods that offer high sensitivity, precision, and reproducibility. ICP-MS, particularly when paired with advanced sample preparation techniques, has become the gold standard for detecting and quantifying both toxic and essential trace elements in baby food.<h4>A streamlined workflow</h4>A recent study showcased a comprehensive workflow using the <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products/1488">Thermo Scientific™ iCAP™ MTX ICP-MS</a> system:<ul><li>Sample preparation: Baby food samples, ranging from dry powders to high-fat and high-moisture items, were processed using microwave-assisted acid digestion. This method ensures uniform preparation and minimizes manual handling.</li><li>Automated dilution: The system’s argon gas dilution (AGD) capability allowed for a consistent five-fold dilution of all samples, accommodating a wide variety of matrices without compromising detection sensitivity.</li><li>Interference management: By leveraging triple quadrupole modes with reactive gases, the ICP-MS effectively suppressed polyatomic and isobaric interferences, ensuring accurate results even for challenging elements like arsenic and mercury.</li><li>Quality control: Calibration curves and internal standard checks maintained accuracy throughout the analysis, with all results aligning within regulatory limits.</li></ul><h4>Key findings</h4>The study analyzed six baby food products, including fruit purees, cereal, yogurt, and fish-based meals. While most samples adhered to safety standards, certain findings highlighted areas for further attention:<ul><li>Arsenic: Elevated levels were detected in salmon-based purees, attributed to organic arsenic compounds naturally present in fish.</li><li>Cadmium and lead: Slightly elevated levels in carrot-based products underscore the need for rigorous soil testing and monitoring.</li></ul><h4>Benefits of advanced ICP-MS analysis</h4>Beyond regulatory compliance, ICP-MS offers additional advantages:<ul><li>Nutritional assessment: Simultaneous analysis of essential nutrients like calcium, iron, and zinc ensures baby food supports healthy growth.</li><li>Efficiency and productivity: The automated workflow minimizes operator intervention, making it suitable for high-throughput laboratories.</li><li>Reliability: Consistent results across diverse sample types build confidence in food safety and quality.</li></ul><h4>Conclusion</h4>Ensuring the safety of baby food is not just a regulatory requirement—it’s a responsibility to protect the youngest and most vulnerable members of our society. By harnessing the power of ICP-MS, manufacturers can confidently address both safety concerns and nutritional needs, delivering products that parents can trust. As technology continues to evolve, such advancements promise a future where baby food safety is guaranteed, one analysis at a time.<a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/cz/en/home/industrial/mass-spectrometry/inductively-coupled-plasma-mass-spectrometry-icp-ms/quadrupole-icp-ms-systems.html">Explore more</a>: Learn how the Thermo Scientific iCAP MTX ICP-MS system is setting new standards in trace metals analysis for food safety.

Ensuring Baby Food Safety: Tackling Toxic Metals with Advanced Technology

<h3>Unlocking the power of triple quadrupole ICP-MS for clinical research: A focus on trace element analysis</h3>Trace elements play a crucial role in various physiological and pathological processes, influencing everything from metabolic function to disease progression. The ability to accurately quantify these elements in biological matrices such as blood, serum, and urine is essential for advancing clinical diagnostics, nutritional studies, and toxicology research. As clinical researchers push the boundaries of precision medicine, the ability to accurately measure trace elements in biological samples has become increasingly critical.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_Cutting_Edge_Triple_Quad_ICP_MS_for_Clinical_Trace_Element_Analysis_62c9f82fee.jpg" alt="Thermo Fisher Scientific: Cutting-Edge Triple Quad ICP-MS for Clinical Trace Element Analysis" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_Cutting_Edge_Triple_Quad_ICP_MS_for_Clinical_Trace_Element_Analysis_62c9f82fee.jpg 245w," sizes="100vw" width="1200" height="600">Traditional techniques often face limitations in sensitivity or may offer access to a limited set of analytes only, but Inductively Coupled Plasma Mass Spectrometry (ICP-MS) overcomes these challenges and offers full multi-element detection with unmatched detection power. It is known as the gold standard for trace element analysis in a variety of other applications, offering unmatched sensitivity, precision, and throughput. Our <a target="_blank" rel="noopener noreferrer" href="https://assets.thermofisher.com/TFS-Assets/CMD/Technical-Notes/tn-003015-tea-icp-ms-icap-mtx-clinical-tn003015-em-en.pdf">latest technical note</a> explores how the <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products/1488">Thermo Scientific iCAP MTX ICP-MS</a> system empowers laboratories to achieve superior analytical performance in clinical research applications<h3>The role of ICP-MS in clinical research</h3>Essential and trace element analysis of biological samples provides significant information to support clinical research and forensic toxicology. For example, the exposure to toxic metals is a known risk factor for several diseases, whereas other elements, when present at appropriate levels, support regular biological function. Concentrations of elements within the blood of a population of subjects can correlate elemental exposure to geographical area, lifestyle, and socio-demographic factors.1<h3>Addressing analytical challenges with the iCAP MTX ICP-MS</h3>However, the analysis of samples containing higher levels of salts and biomolecules, such as proteins or metabolites is a known challenge in ICP-MS analytical techniques. The complexity of the sample matrix can significantly affect the sensitivity of the instrument, cause intensity fluctuation of the internal standard (suppression and drift), and lead to increased system maintenance with unwanted downtime due to obstruction of the interface cones, torch, and injector, or the nebulizer. In addition, the development of a multi-element method is challenging due to the wide concentration ranges that need to be covered across essential and toxic elements and the wide range of potential interferences from the sample matrix. These complex prerequisites often mean that triple quadrupole ICP-MS instruments are the best choice for analysis. The <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products/1488">iCAP MTX ICP-MS system </a>addresses key challenges in trace element analysis, including:<ul><li>Enhanced sensitivity and accuracy: The triple quadrupole design improves detection limits, ensuring reliable quantification of even ultra-trace elements.</li><li>Matrix interference elimination: The system employs advanced interference removal techniques, delivering high-quality data even in complex biological samples.</li><li>Workflow efficiency: Designed for high-throughput laboratories, the system enhances productivity by streamlining sample preparation and data processing.</li></ul> The iCAP MTX ICP-MS was employed to analyze 43 elements in whole blood samples. Among the analytes, several critical interferences can cause unexpected bias, which were investigated closely for effective and complete removal by means of selective collision / reaction cell reactions with oxygen. This analytical method was rigorously tested, and the results obtained clearly demonstrated analytical advantages:<ul><li>The combination of He KED and TQ-O2 mode allows for effective suppression of typical interferences, which enables high sensitivity required for the accurate determination of the entire mass range (lithium to uranium) and a linear response for all analytes, which cover a concentration range of 8 orders of magnitude (Table 1).</li><li>The <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products/1715">Thermo Scientific iSC-65 Autosampler</a> equipped with the Step Ahead feature allowed for a reduction of the total analysis time, and in combination with intelligent Matrix Handling, the analysis of whole blood could be carried out with improved productivity.</li><li>The use of TQ-O₂ mode allowed removal of interferences of any kind, especially on key analytes such as common transition metals, and toxic/essential elements such as arsenic or selenium in the 50-fold diluted whole blood samples. Figure 1 shows the TQ-O2 mode and a mass shift reaction for interference free detection of As and Ti.</li></ul>Table 1. Summary of analysis mode, and calibration results, R2, LODs, and MDLs for all analytes. All numbers are shown in μg·L-1.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_Cutting_Edge_Triple_Quad_ICP_MS_for_Clinical_Trace_Element_Analysis_2_7a23fca938.jpg" alt="Thermo Fisher Scientific: Cutting-Edge Triple Quad ICP-MS for Clinical Trace Element Analysis: Table 1. Summary of analysis mode, and calibration results, R2, LODs, and MDLs for all analytes. All numbers are shown in µg·L-1." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_Cutting_Edge_Triple_Quad_ICP_MS_for_Clinical_Trace_Element_Analysis_2_7a23fca938.jpg 30w," sizes="100vw" width="676" height="3476"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_Cutting_Edge_Triple_Quad_ICP_MS_for_Clinical_Trace_Element_Analysis_3_73d4ef0ad1.jpg" alt="Thermo Fisher Scientific: Cutting-Edge Triple Quad ICP-MS for Clinical Trace Element Analysis: Figure 1. Schematic showing the use of TQ-O 2 mode and a mass shift reaction for interference free detection of arsenic (As) and titanium (Ti)." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_Cutting_Edge_Triple_Quad_ICP_MS_for_Clinical_Trace_Element_Analysis_3_73d4ef0ad1.jpg 245w," sizes="100vw" width="700" height="410"><ul><li>The total analysis time was 3 min 14 s per sample (including uptake and wash time) for 43 elements. This is specifically for large cohort studies, for example to screen exposure in a representative population.</li><li>Robust and stable analytical performance was demonstrated over 15 hours of continuous acquisition of 287 samples by the iCAP MTX ICP-MS with excellent CCV results. Figure 2 shows the highly reproducible internal standard responses over the entire batch, demonstrating robust analytical performance.</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_Cutting_Edge_Triple_Quad_ICP_MS_for_Clinical_Trace_Element_Analysis_4_b2a1f3f2aa.jpg" alt="Thermo Fisher Scientific: Cutting-Edge Triple Quad ICP-MS for Clinical Trace Element Analysis: Figure 2. Response of the internal standards in a batch covering about ~15 hours of uninterrupted analysis of 287 samples." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_Cutting_Edge_Triple_Quad_ICP_MS_for_Clinical_Trace_Element_Analysis_4_b2a1f3f2aa.jpg 245w," sizes="100vw" width="700" height="207"><article><div><blockquote>Visit us on <a target="_blank" rel="noopener noreferrer" href="https://www.linkedin.com/showcase/72003132/admin/dashboard/">LinkedIn:</a> #ClinicalResearch #TraceElementAnalysis #ICPMS #LaboratoryInnovation</blockquote></div></article><section><blockquote><h5>Daniel Kutscher</h5>Dr. Daniel Kutscher manages the Application Development for trace elemental analysis and GC/GC-MS products at the Thermo Fisher Scientific Center of Excellence in Mass Spectrometry in Bremen, Germany. After graduation in Chemistry in 2007, Daniel obtained his PhD from the University of Oviedo in 2011. In the same year, he joined Thermo Fisher Scientific and has had different roles in application development and marketing.</blockquote></section>

Cutting-Edge Triple Quad ICP-MS for Clinical Trace Element Analysis

Our Library never stops expanding. What are the most recent contributions to LabRulezICPMS Library in the week of 19th May 2025? Check out new documents from the field of spectroscopy/spectrometry and related techniques!<blockquote>👉 <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library">SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT SPECTROSCOPY/SPECTROMETRY RELATED TECHNIQUES</a></blockquote><blockquote>👉 Need info about different analytical techniques? Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library">LabRulezLCMS</a> or <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library">LabRulezGCMS</a> libraries.</blockquote>This week we bring you other document by Agilent Technologies, guide by Shimadzu and brochure by Thermo Fisher Scientific!<h3>1. Agilent Technologies: 5 Reasons You Need Onsite Metals Analysis Capabilities for Battery Recycling</h3><ul><li>Other document</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/quickref_battery_recycling_infographic_icp_oes_5994_8002en_agilent_024ec4b399.pdf">Full PDF for download</a></li></ul>1. Monitoring airborne particulates&nbsp;Mechanical separation e.g. shredding, creates airborne particulates, hazardous to human health and the environment. ICP-OES can be used to monitor air filters to ensure regulatory compliance.&nbsp;2. Analyzing black mass&nbsp;The powder from separation, known as “black mass”, is widely refined through hydrometallurgical and pyrometallurgical processes. ICP-OES effectively measures impurities to ensure the final product quality meets specifications.&nbsp;3. Monitoring and optimizing recycling processes&nbsp;Efficient separation is vital for effective downstream processing. Onsite ICP-OES enables real-time monitoring and optimization at each stage, maximizing material recovery like feedstock chemicals.&nbsp;4. Ensuring QC of input chemicals&nbsp;Purity of chemicals used in battery recycling is crucial to avoid introducing contaminants in the final product. For example, leaching – a common purification step – uses strong acids and solvents to isolate compounds.5. Monitoring environmental discharges&nbsp;Thorough chemical analysis of emissions and waste can be achieved using ICP-OES to ensure the correct and safe disposal of these by-products.<h3>2. Shimadzu: Application Data Book - Polymer and Electronic Material</h3><ul><li>Guide</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/c160_e010_c8512bcb71.pdf">Full PDF for download</a></li></ul>The Shimadzu "Thermal Analysis 60 Series Application Data Book" is a comprehensive technical compendium showcasing the use of Shimadzu thermal analysis instruments—primarily the<a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?manufacturerItems=3&amp;search=+DSC-60"> DSC-60</a>, <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?manufacturerItems=3&amp;search=DTG-60">DTG-60</a>, and <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?manufacturerItems=3&amp;search=TGA-50">TGA-50</a>—for analyzing a wide array of polymeric and electronic materials. This application-focused book is structured into several sections that highlight practical case studies across categories such as plastics, electronic materials, and battery components, demonstrating how thermal techniques can be used to measure melting behavior, crystallization, decomposition, and glass transition properties.In the section dedicated to plastics, studies examine the thermal responses of materials such as PET, PEEK, nylon, polypropylene, and polyimide. The influence of thermal history on crystallinity and thermal stability is highlighted through differential scanning calorimetry (DSC) analyses. For instance, the book explains how rapid cooling affects PET’s amorphous structure and how glass transition shifts depending on sample morphology and processing history. Shimadzu’s DSC-60 is used throughout to detect transitions such as glass transitions and melting points with high sensitivity and resolution.When analyzing electronic materials, the book includes examples such as thermal decomposition of diodes and quantification of quartz in epoxy resins. Using Shimadzu’s DTG-60, these analyses reveal how semiconductor components decompose and how fillers like quartz contribute to thermal resistance. Similarly, for lead-free solder materials, melting behavior is compared to traditional Sn-Pb alloys, emphasizing the importance of composition in defining thermal performance—a critical aspect in electronics manufacturing.The section on battery and fuel cell materials underscores the role of thermal analysis in energy-related applications. Using the DSC-60, separators in lithium-ion batteries are examined for their melting characteristics, which are crucial for safety mechanisms. The book also delves into analyzing Nafion® membranes for polymer fuel cells, using DSC to interpret water cluster dynamics that influence conductivity. These examples collectively illustrate how Shimadzu’s thermal analysis instruments provide valuable insights into the thermal behavior of modern materials used across diverse industries.<h3>3. Thermo Fisher Scientific: Thermo Scientific <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products/1715">iSC-65 Autosampler</a> and <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products/1489">Qtegra ISDS Software</a>: reliability to power through your challenging ICP-OES and ICP-MS workflows</h3><ul><li>Brochure</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/sl_001587_tea_isc_65_autosampler_and_qtegra_isds_software_sl001587_en_0809719473.pdf">Full PDF for download</a></li></ul>The <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products/1715">Thermo Scientific™ iSC-65 Autosampler</a>, controlled by <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products/1489">Thermo Scientific™ Qtegra™ Intelligent Scientific Data Solution™ (ISDS) Software</a>, is a robust, feature-rich sample introduction system with advanced hardware and software capabilities designed to improve productivity and profitability in your routine workflow.&nbsp;The iSC-65 Autosampler is compatible with the Thermo Scientific™ <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products?category=231&amp;manufacturerItems=3&amp;search=icap+pro+icp-oes">iCAP™ PRO Series ICP-OES</a> and iCAP™ Qnova Series ICP-MS instruments. It is ideally suited for use in applications in environmental, food, industrial, battery technology, sustainable fuels, petrochemical, and pharma markets that require reliable sampling over extended periods.&nbsp;<h5>Key hardware features&nbsp;</h5><ul><li>An industry-proven three-axis screw thread design reliably drives the sample probe with sub mm accuracy and precision.&nbsp;</li><li>Materials that are resistant to common chemicals and acid are used throughout, allowing for reliable, contamination-free operation over extended periods.&nbsp;</li><li>Up to four industry standard sample racks can be installed at one time. Racks with vial capacities of 21, 24, 40, 60, and 90 are supported.&nbsp;</li><li>A dedicated area for 50 mL (either flat or round base) tubes is provided, ideal for solutions that need to be repeatedly analyzed, for example, quality control standards.</li><li>In case of accidental spillage, the sample rack tray can be removed, and fittings are provided to support either a gravity drain to the front or a pumped drain to the rear of the iSC-65 Autosampler.&nbsp;</li><li>The two-channel rinse station is fed by a dedicated rinse pump that can be used to remove excess rinse solution or fitted to a gravity drain. The rinse station is removable for cleaning and is connected to tubing with luer style fittings for ease of use and peace of mind.&nbsp;</li></ul><h5>Key sampling capabilities&nbsp;</h5><ul><li>Step Ahead – sends the probe to the rinse station during data acquisition, using the sample volume in the probe and transfer tubing to complete the analysis. Less sample solution is required, decreasing waste and instrument wear, and less time is required to rinse, reducing rinse solution usage and accelerating sample throughput. &nbsp;</li><li>Flexible sampling depths – vial-specific probe depths enable correct sampling to avoid suspended particles that could otherwise lead to blockages, minimizing maintenance and potential exchange of sample introduction components.</li></ul><h5>Software features built on hardware capabilities&nbsp;</h5><ul><li>The Thermo Scientific iSC-65 Autosampler is controlled through a dedicated software plug-in within the Qtegra ISDS Software platform. A high clarity, easy to follow, visual workflow is carried through multiple views.&nbsp;</li><li>A dedicated view for the iSC-65 Autosampler is accessible in the Qtegra ISDS Software Dashboard that provides access to common autosampler actions – probe movement, pump speed control, etc.</li></ul>

News from LabRulezICPMS Library - Week 21, 2025

Our Library never stops expanding. What are the most recent contributions to LabRulezICPMS Library in the week of 30th June 2025? Check out new documents from the field of spectroscopy/spectrometry and related techniques!<blockquote>👉 <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library">SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT SPECTROSCOPY/SPECTROMETRY RELATED TECHNIQUES</a></blockquote><blockquote>👉 Need info about different analytical techniques? Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library">LabRulezLCMS</a> or <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library">LabRulezGCMS</a> libraries.</blockquote>This week we bring you posters by Agilent Technologies / ASMS and Thermo Fisher Scientific / ASMS!<h3>1. Agilent Technologies / ASMS: Measurement of Metals in Tissue Samples Using Laser Ablation-ICP-MS and an Organic Matrix-Based Standard</h3><ul><li>Poster</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/ps_8890_la_icp_ms_metals_tissue_asms_2025_thp_067_en_agilent_ee9bc7a285.pdf">Full PDF for download</a></li></ul>Laser Ablation-Inductively Coupled Plasma-Mass Spectroscopy (LA-ICP-MS) can provide localization information of elements on solid samples. Therefore, bioimaging techniques using LA-ICP-MS have been developed to investigate the distribution of metals on thin sections.&nbsp;Primary biliary cholangitis (PBC) is an autoimmune disorder that primarily targets the interlobular bile ducts. The resulting bile duct damage causes chronic cholestasis in the liver, which can eventually progress to cirrhosis. It is well-established that individuals with PBC exhibit impaired copper (Cu) excretion, leading to Cu accumulation within the liver.&nbsp;Pathologists have employed orcein or Victoria blue staining to visualize Cu deposition in pathological specimens. 1 Orcein staining is commonly used to assess the stage of PBC. However, both staining methods measure Cu levels indirectly by detecting Cu-binding proteins, which introduces significant variability in measurement accuracy across different facilities and yields relatively low detection sensitivity.&nbsp;The aim of the study was to directly quantify Cu in PBC specimen using LA-ICP-MS, a highly sensitive technique, and compare the results with that obtained from normal-looking tissue in liver. The elemental concentrations were determined from external calibration curves generated using an organic matrix-based standard (Solid scaleTM, FUJIFILM Wako Chemicals).&nbsp;<h4>Conclusions</h4>This study demonstrates the high performance of the Agilent <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?mainauthorItems=10&amp;search=8900+ICP-QQQ">8900 ICP-QQQ</a> equipped with an ESL 213 laser ablation system for bioimaging human liver specimens.&nbsp;<ul><li>An organic matrix-based standard (Solid scaleTM ) provided quantitative results of metals in human liver specimens.&nbsp;</li><li>Patterns of metal distribution (24Mg, 31P, 44Ca, 56Fe, 63Cu, 95Mo) in human liver showed accumulation of Cu in a PBC specimen and its unique localization pattern along the regenerative nodule.&nbsp;</li></ul>These results demonstrate that determining metal concentrations in thin sections using LA-ICP-MS provides valuable insights into the mechanisms of PBC and other metal-related diseases.<h3>2. Thermo Fisher Scientific / ASMS: Trace metals analysis in baby food using triple quadrupole inductively coupled plasma mass spectrometry (TQ-ICP-MS)</h3><ul><li>Poster</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/PO_296_ASMS_25_metals_baby_food_TQ_ICP_MS_na_en_3c869a51aa.pdf">Full PDF for download</a></li></ul>Many countries have established their own regulations and guidelines to ensure the safety and quality of baby food products. These regulations are generally based on scientific research and risk assessments conducted by health and food safety authorities. Among a range of other contaminants, toxic heavy metals, such as lead, arsenic, cadmium, and mercury, are subject to screening.&nbsp;The Baby Food Safety Act of 2021 requires manufacturers and the FDA to take long overdue action by setting maximum levels of inorganic arsenic (10 μg∙kg-1, 15 μg∙kg-1 for cereal), lead (5 μg∙kg-1, 10 μg∙kg-1 for cereal), cadmium (5 μg∙kg-1, 10 μg∙kg-1 for cereal), and mercury (2 μg∙kg-1) allowed in baby food.&nbsp;Since January 2022, baby food manufacturers need to meet these maximum levels for toxic elements by testing their final products (because only ingredient testing significantly underestimates toxic heavy metal levels in the final product), and to post the results of their product testing online twice per year. Similarly, as the FDA is working on a “closer to zero plan”, the European Union has established regulations and maximum limits for various contaminants, including toxic elements, in baby food. ICP-MS (inductively coupled plasma mass spectrometry) is the commonly used analytical technique to measure trace elements in various samples, including baby food. The specific trace elements to be checked by ICP-MS in baby food may vary depending on the purpose of the analysis and the specific concerns related to the safety and quality of the product.<h4>Materials and methods&nbsp;</h4><h5>Instrumentation&nbsp;</h5>A <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products/1488">Thermo Scientific iCAP MTX ICP-MS</a> and a Thermo Scientific <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products/1715">iSC-65 Autosampler</a> were used for analysis. The ICP-MS was operated using the parameters highlighted in Table 1. To facilitate the robustness to analyze a high number of potentially very different sample types, the instrument was operated using argon gas dilution (AGD), applying a mild (approximately 5 times) dilution to all samples. This ensures the productivity and uptime requirements in a high productivity laboratory environment can be met. To meet the stringent detection limit requirements put in place by regulatory authorities, the iCAP MTX ICP-MS was operated in SQ-KED and TQ-O2 modes to confidently eliminate all polyatomic and isobaric interferences but also deliver the sensitivity needed to reach the requested quantification limits for the critical elements.<h4>Results&nbsp;</h4>Table 3 summarizes the analytical figures of merit for all analytes including the correlation coefficients, the limits of quantification, and the quantification limits of the method (MLOQ). Whereas the limit of quantification (LOQ) only considers what can be quantified by the instrument, the method quantification limit (MLOQ) also accounts for the complete sample preparation, i.e., the sample weight and the dilution factor. Specifically highlighted in the table are the results obtained for As, Cd, Hg, and Pb, elements which are of specific regulatory concern due to their toxicity and risk for bioaccumulation. As can be seen, the achieved MLOQs are at least a factor two lower compared to the nominal limits specified in EAM 4.7.<h4>Conclusions&nbsp;</h4>This workflow, combining sample preparation using microwave assisted digestion and analysis using the iCAP MTX ICP-MS, allows accurate measurement of the concentration of toxic elements, dangerous for children, as well as the essential elements, necessary for the good growth and health of children, in various baby food products.&nbsp;<ul><li>The automatic and constant 5-times dilution allows robust analysis of different types of baby food products, whether dry, liquid, or fatty, without any compromise on sensitivity to reach the regulated limits.&nbsp;</li><li>The stability of the iCAP MTX ICP-MS allows a large variety of different food samples can be analyzed in the same run, ensuring productivity in an applied testing laboratory.&nbsp;</li><li>All types of interferences (polyatomic as well as isobaric interference, including doubly charged ions) are effectively suppressed with either helium collision gas or by using oxygen as a reactive gas in triple quadrupole mode.&nbsp;</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products/1489">Qtegra ISDS Software</a> with the Reaction Finder functionality, allows simplified handling for the operator by automatically defining the isotopes and the acquisition modes to obtain reliable results.&nbsp;</li><li>The maintenance assistant also ensures alerts to the user when actions need to be carried out by the operator to guarantee an instrument with best performance throughout instrument lifetime.</li></ul>

News from LabRulezICPMS Library - Week 27, 2025

Our Library never stops expanding. What are the most recent contributions to LabRulezICPMS Library in the week of 8th September 2025? Check out new documents from the field of spectroscopy/spectrometry and related techniques!<blockquote>👉 <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library">SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT SPECTROSCOPY/SPECTROMETRY RELATED TECHNIQUES</a></blockquote><blockquote>👉 Need info about different analytical techniques? Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library">LabRulezLCMS</a> or <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library">LabRulezGCMS</a> libraries.</blockquote>This week we bring you brochure by Agilent Technologies, other document by Shimadzu and poster by Thermo Fisher Scientific!<h3>1. Agilent Technologies: Consumable Solutions for Semiconductor Analysis</h3><ul><li>Brochure</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/og_csd_semiconductor_analysis_workflow_5994_5101en_agilent_631b673735.pdf">Full PDF for download</a></li></ul>Since the late 1980s, Agilent has worked closely with semiconductor manufacturers and chemical suppliers to advance analytical technologies that support the entire semiconductor supply chain. With instruments such as ICP-MS, ICP-QQQ, GC/MS, and LC/MS, Agilent provides reliable methods for process monitoring, raw material quality control, detection of inorganic and organic impurities, nanoparticle analysis, and compliance with environmental and safety standards.A critical aspect of semiconductor manufacturing is the use of electronic wet chemicals, which must achieve ultra-high purity levels to prevent contamination. These chemicals include general-purpose acids, bases, and solvents, as well as functional reagents like photoresists, etching solutions, and cleaning agents. To ensure accurate impurity detection in these materials, Agilent offers a comprehensive range of consumables designed specifically for ICP-MS and ICP-QQQ systems.The portfolio covers configurations optimized for different chemical environments, including inorganic aqueous reagents, hydrofluoric acid–compatible materials, organic solvent testing, and silicon wafer vapor phase decomposition (VPD). Consumables such as nebulizers, spray chambers, torches, sampler and skimmer cones, and inert sample introduction kits are tailored to withstand aggressive acids, volatile solvents, and high-matrix samples. These solutions not only ensure reliable results but also extend instrument life and minimize downtime.Beyond sample introduction, Agilent provides essential general supplies such as high-purity argon gas filters, waste container kits, cleaning tools, and tuning solutions. Together, these consumables support the robustness and consistency of semiconductor impurity testing workflows, enabling manufacturers to maintain yield and quality in one of the most contamination-sensitive industries.<h3>2. Shimadzu: Perform Microplastics Analysis More Quickly and Accurately</h3><ul><li>Other Document</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/c103_e154_9330a3e4e8.pdf">Full PDF for download</a></li></ul>Shimadzu has introduced new options for the <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?mainauthorItems=1&amp;search=AIMsight+infrared+microscope">AIMsight™ infrared microscope</a> and the <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?mainauthorItems=1&amp;search=AIRsight">AIRsight™ infrared/Raman microscope</a>, designed to improve the speed and accuracy of microplastics and contaminant analysis. By adding the new Particle Analysis Program to AMsolution software, users can automatically measure the size, mass, and volume of multiple particles and easily visualize the results through graphs and tables.The program calculates particle dimensions such as major and minor axes, while also estimating mass and volume using a validated theoretical formula based on recent research from Ehime University. This allows laboratories to determine microplastic mass concentrations with high accuracy, a significant improvement over traditional methods. Statistical data, including component ratios and histograms, can be output directly or exported in CSV format, while customizable analysis conditions allow exclusion of unwanted particle types like fibers.To further enhance measurement reliability, Shimadzu offers a Particle Filter (PF) Holder. This accessory secures PTFE or stainless steel membrane filters to prevent sagging during drying, keeping the surface level and ensuring more precise focusing and particle detection.Together, the AIMsight and AIRsight microscopes, combined with the Particle Analysis Program and PF Holder, provide laboratories with a powerful, automated solution for high-throughput, reproducible microplastics research and contaminant monitoring.<h3>3. Thermo Fisher Scientific: Analysis of whole blood samples using triple quadrupole inductivity coupled plasma mass spectrometry (ICP-MS)</h3><ul><li>Poster</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/po_whole_blood_triple_quadrupole_inductivity_coupled_plasma_ms_icp_po_en_4b667f10bc.pdf">Full PDF for download</a></li></ul>Elemental analysis of blood is essential for clinical research, toxicology, and occupational health studies. While some elements are required for biological function, others can pose health risks when present even at trace levels. Because blood is a complex matrix rich in salts and biomolecules, it presents significant challenges for accurate and reproducible analysis. Triple quadrupole ICP-MS is particularly well suited for this task, offering high sensitivity, robust interference removal, and wide dynamic range.In this study, researchers applied the <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products/1488">Thermo Scientific™ iCAP™ MTX ICP-MS</a> equipped with an <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products/1715">iSC-65 Autosampler</a> and operated using <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products/1489">Qtegra™ ISDS software</a>. Whole blood samples were diluted 50-fold and analyzed for 43 elements ranging from lithium to uranium. By combining He KED mode with TQ-O₂ mass-shift reactions, the method effectively removed spectral interferences, enabling accurate detection across eight orders of magnitude—from sub-ng/L levels up to 50 mg/L.Performance testing demonstrated excellent accuracy, with results closely matching certified reference materials for whole blood. The setup also showed outstanding robustness, sustaining more than 15 hours of continuous acquisition for 287 samples with minimal drift. The Step Ahead feature of the autosampler reduced analysis time by 9%, while the humidifier and interface maintenance hardware improved stability and minimized downtime. Notably, after over 1,000 sample injections, the sampler and skimmer cones remained clean, underlining the durability of the system.The study also compared human, horse, and pig blood, revealing significant differences in elemental composition between species. These findings highlight the potential of triple quadrupole ICP-MS to accelerate large-scale studies on biological variation and exposure assessment. Together, the iCAP MTX ICP-MS and iSC-65 Autosampler provide a powerful, high-throughput solution for multi-element analysis in one of the most challenging sample types: whole blood.

News from LabRulezICPMS Library - Week 37, 2025

<h3>Lunch &amp; learn tips &amp; tricks series 2026 – part 1</h3>In modern analytical laboratories, efficiency, consistency, and data confidence are essential. Whether you are operating an ICP-OES or ICP-MS system, the way you use your software can significantly influence productivity and analytical performance. In the first session of our Lunch &amp; Learn Tips &amp; Tricks Series, we focused on one of the most common themes raised by users: how to navigate <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products/1489">Qtegra </a>software more effectively and optimize everyday workflows.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_Mastering_Qtegra_Software_Practical_Strategies_to_Improve_Your_Daily_Lab_Workflow_3d35454782.jpg" alt="Thermo Fisher Scientific: Mastering Qtegra Software: Practical Strategies to Improve Your Daily Lab Workflow" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_Mastering_Qtegra_Software_Practical_Strategies_to_Improve_Your_Daily_Lab_Workflow_3d35454782.jpg 245w," sizes="100vw" width="1024" height="512">This session explored three key areas in detail: understanding the structure of Qtegra and the Configurator, using the Dashboard as your operational control center, and building smarter, more efficient LabBooks. Below is a structured recap of the key insights shared during Part 1.<h3>Understanding the structure of Qtegra</h3>One of the most valuable features of Qtegra software is its consistency across multiple instrument platforms. Whether you are working with the <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products?category=227&amp;instrumentationItems=84&amp;manufacturerItems=3&amp;search=icap+pro">iCAP PRO ICP-OES</a>, the <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products?category=232&amp;instrumentationItems=83&amp;manufacturerItems=3">iCAP MX ICP-MS</a>, the iCAP 7000 OES, or Qnova ICP-MS systems, the interface and workflow logic remain familiar. This consistency reduces the learning curve when transitioning between instruments and supports standardised training across laboratories.Qtegra consists of two primary components: the Qtegra application itself and the Configurator.<ul><li>The Qtegra application is where you directly interact with your instrument. It is used to create LabBooks, control the instrument, execute analyses, and review results.</li><li>The Configurator, in contrast, defines how your system behaves at a deeper level. It controls system-level settings that underpin daily operation. Within the Configurator, users can manage features such as Fast Uptake setup, drain sensor configuration, wavelength libraries for ICP-OES systems, the Reaction Database for ICP-MS systems, and user access permissions.</li></ul>Understanding the distinction between these two components helps users troubleshoot more effectively and ensures that system configuration aligns with laboratory requirements.<h3>Using the dashboard as your central hub</h3>When Qtegra is opened, the first screen presented is the Dashboard. The Dashboard functions as the central hub for instrument monitoring and control. From this location, users can view instrument status, monitor live operating parameters, access tuning tools, review performance checks, and identify error or interlock notifications.<ul><li>For ICP-OES users, the Dashboard provides access to tune sets, source settings, AutoPeak alignment, autotuning functions, and live views such as Plasma TV. These tools allow users to confirm that the plasma and optical system are performing as expected before analysis begins.</li><li>For ICP-MS users, the Instrument tab within the Dashboard provides access to autotune routines, performance report summaries, gas flow settings, nebuliser adjustments, operating mode selection such as Standard, KED, or CCT modes, IntelliLens control, and real-time data streams.</li></ul>The Dashboard should be used as a structured checkpoint before running any analysis. Confirming that all parameters are within acceptable ranges reduces the likelihood of interruptions and supports consistent performance throughout the run.<h3>The get ready workflow: structured instrument preparation</h3><ul><li>The Get Ready function, which is launched directly from the Dashboard, provides a guided preparation workflow. This feature is designed to ensure that the instrument is fully configured and operating correctly for the selected method before analysis begins.</li><li>Within Get Ready, users can access scheduling tools that automate warmups, standby routines, shutdowns, and maintenance checks. These tools are particularly beneficial for laboratories operating multiple shifts or managing variable workloads.</li></ul>For ICP-MS systems, the Get Ready workflow includes automated performance checks, autotune routines, and controlled warm-up conditions. These routines verify that the instrument is operating within its expected performance range.By following the structured steps within Get Ready, laboratories can reduce the risk of missed preparation tasks and maintain day-to-day analytical consistency.<h3>Building smarter LabBooks</h3>The LabBook forms the foundation of every analytical sequence in Qtegra. A carefully constructed LabBook improves efficiency, reduces setup errors, and simplifies data review.Users can create a LabBook from scratch or begin with a template. Templates are particularly useful for laboratories that integrate with LIMS systems or import sample lists via CSV files, as they promote standardisation and consistency.<h4>Defining analytes</h4><ul><li>For ICP-OES methods, users must select appropriate wavelengths and evaluate potential spectral interferences.&nbsp;</li><li>For ICP-MS methods, users select the required masses, consider isobaric and polyatomic interferences, and use the Reaction Database to support reaction mode selection.</li></ul>Careful analyte selection at this stage helps prevent complications later in the analytical workflow.<h4>Configuring acquisition parameters</h4>Acquisition parameters define how the instrument collects data.<ul><li>For ICP-OES systems, this includes selecting viewing modes, choosing wavelength ranges such as iFR or eUV, and defining integration times.</li><li>For ICP-MS systems, this includes selecting operating modes such as Standard, KED, or CCT, configuring Reaction Finder options, enabling Intelligent Matrix Handling, and defining digital trigger settings.</li></ul>Thoughtful parameter configuration ensures that data quality objectives are met without unnecessary reanalysis.<h4>Using intelligent uptake and rinse</h4>The Intelligent Uptake and Rinse feature detects when the sample or rinse solution reaches the nebuliser. This ensures consistent timing across samples and improves overall throughput. In high-throughput environments, this feature contributes to both efficiency and reproducibility.<h4>Calibration and quantification strategy</h4>Calibration design is central to reliable quantification. Qtegra allows users to manage global standards, configure dilution tools, select calibration fit types, assign internal standards, and establish quality control samples.For ICP-OES systems, users can define standard ranges and switch points. For SemiQuant workflows, Relative Sensitivity Factors can be applied.Establishing these parameters during LabBook creation ensures that data validation is straightforward once analysis is complete.<h4>Autosampler and sample list setup</h4>For laboratories using the <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products/1715">iSC-65 autosampler</a>, features such as StepAhead, custom rack definitions, colour-coded sample views, and visual integrity checks support efficient sequence management.When constructing the sample list, users should clearly define sample types, establish a logical sequence order, and configure column layouts appropriately. Setting flags and limits during initial setup simplifies the data review process and supports quality assurance.<h3>Why workflow optimisation matters</h3>Optimising Qtegra usage does not require learning new software features. Instead, it involves using existing tools more strategically. By treating the Dashboard as a pre-run checkpoint, using Get Ready consistently, and constructing LabBooks with long-term efficiency in mind, laboratories can reduce downtime, improve reproducibility, and strengthen confidence in analytical results.<h3>Looking ahead to part 2</h3><blockquote>In Part 2 of the Qtegra Tips &amp; Tricks series, we will focus on post-analysis best practices. Topics will include interpreting signal intensities, reviewing calibration performance, evaluating recoveries and readbacks, applying flags effectively, exporting data, and implementing practical workflow improvements discussed in Part 1.</blockquote>By building a structured approach to both preparation and data review, laboratories can transform routine analysis into a streamlined, reliable, and repeatable process.We look forward to continuing the discussion in Part 2.<h5>Acknowledgement</h5>I would like to thank Matthew Gregory Field Applications Scientist, North EMEA, Trace Elemental Analysis and David Fishwick Field Applications Scientist, North EMEA, Trace Elemental Analysis for the support on this blog and the webinars<h4>Sign up for our webinars live and on demand.</h4>English<ul><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/5795">Lunch and Learn Tips and Tricks Series: Qtegra Part 1</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/5976">Lunch and Learn Tips and Tricks Series: Qtegra Part 2</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/5977">Lunch and Learn Tips and Tricks Series: Trace Elemental Analysis (ICP-OES &amp; ICP-MS)</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/5978">Trace Elemental Analysis: Ask the Expert</a></li></ul>Deutsch<ul><li>19. März 2026 <a target="_blank" rel="noopener noreferrer" href="https://event.on24.com/wcc/r/5179134/393E071E3B501943730958BA6203F477">Interne Standards in der ICP-OES: Ein Praxisguide für zuverlässige Qualitätssicherung im Labor</a></li><li>18. Juni 2026 <a target="_blank" rel="noopener noreferrer" href="https://event.on24.com/wcc/r/5179292/AE4C576B6A54D1AC182F7F77573D380F">Fehler reduzieren, Durchsatz steigern: Autoverdünnung mit PrepFast am ICP-MS</a></li><li>17. September 2026 <a target="_blank" rel="noopener noreferrer" href="https://event.on24.com/wcc/r/5179423/B5019C560431BADCA2A76E54E4EFE56F">ICP-OES smarter nutzen: Probendurchsatz erhöhen, Ressourcen sparen</a></li><li>17. Dezember 2026 <a target="_blank" rel="noopener noreferrer" href="https://event.on24.com/wcc/r/5179530/94EEDD1F56138F5EEE2AF24E29E6C12A">Qtegra ISDS Software Unlocked – Live im Expertengespräch</a></li></ul>Visit us on&nbsp;<a target="_blank" rel="noopener noreferrer" href="https://www.linkedin.com/showcase/72003132/admin/dashboard/">LinkedIn:</a>&nbsp;#Qtegra, #ICPMS, #ICPOES, #TraceElementalAnalysis<blockquote><h5>Petra Gerhards</h5>Petra Gerhards, Dipl-Ing, is Regional Marketing Manager of GC and GC-MS for EMEA at Thermo Fisher Scientific. She has more than 29 years of experience in the fields of GC-MS, SPE and LC-MS. Since joining the regional team she has contributed to workflow solutions combining vials and closures with SPE solutions, GC-MS and LC-MS. She works with KOL's on data for regional specific marketing campaigns, organizes in-house seminars and works on customer specific solutions. Her main expertise is in the field of doping and drugs-of-abuse analysis.</blockquote>

Mastering Qtegra Software: Practical Strategies to Improve Your Daily Lab Workflow

In <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products?category=227&amp;manufacturerItems=3">ICP-OES</a> analysis, maintaining reliable accuracy and precision over time can be challenging. Instrument drift, matrix effects, and fluctuations in sample introduction can all influence analytical results. One of the most effective tools to monitor and compensate for these influences is the internal standard (ISTD). When properly selected and implemented, an internal standard significantly strengthens quality assurance and increases confidence in analytical data.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_Internal_Standards_in_ICP_OES_A_Practical_Guide_to_Better_Accuracy_and_Precision_50d02d62c8.jpg" alt="Thermo Fisher Scientific Internal Standards in ICP-OES A Practical Guide to Better Accuracy and Precision" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_Internal_Standards_in_ICP_OES_A_Practical_Guide_to_Better_Accuracy_and_Precision_50d02d62c8.jpg 245w," sizes="100vw" width="1024" height="512">An internal standard is a suitable element that is added at a constant concentration to all blanks, calibration standards, quality control samples, and unknown samples. It is measured simultaneously with the analytes of interest and serves as an indicator of what is happening during the measurement process. Because it behaves similarly to the analytes in the plasma, it reflects variations that occur during sample transport, excitation, or detection.However, not every element qualifies as a good internal standard. Ideally, the chosen element should not be present in the sample, or only in negligible amounts. It must not cause spectral interferences with the analytes, and its emission line should remain free from interference itself. The internal standard should also be compatible with the sample matrix and exhibit similar excitation and ionization characteristics to the analytes. In practice, the internal standard is typically introduced at a concentration of approximately 1 to 5 ppm at the nebulizer, ensuring a clean and stable signal.When correctly applied, internal standards help correct for several types of variation. They compensate for changes in sample transport caused by pump instability or nebulizer fluctuations. They correct for plasma instability and optical drift over time. They also address certain matrix-related effects, such as changes in viscosity or surface tension that influence aerosol formation and excitation efficiency. By normalizing the analyte signal to the internal standard signal, many physical and instrumental variations can be effectively minimized.It is important to understand, however, what internal standards cannot correct. They do not resolve spectral overlaps or interferences. They cannot compensate for incorrect calibration or non-linear response behavior. Detector saturation and fundamental method errors also remain unaffected by internal standard correction. In other words, an internal standard enhances a well-designed method but cannot rescue a flawed one.Internal standards are particularly valuable in long analytical sequences, where system drift can gradually affect results. By continuously monitoring the internal standard signal, laboratories can detect and correct drift in real time. They are also helpful in sequences involving strongly varying sample matrices. Differences in density or viscosity between samples can influence transport efficiency, and the internal standard provides a way to monitor and partially compensate for these effects.Another important application of internal standards is in high-precision analysis. In precious metal determinations, for example, internal drift correction can be applied to each individual measurement. When combined with a bracketing approach, this technique can dramatically improve overall precision. In one example presented, a total precision of 0.07% over twelve measurements was achieved despite variability in individual readings. Such performance illustrates the strength of internal standard correction when precision requirements are demanding.There are two main approaches to introducing the internal standard into the ICP-OES system. In the classical approach, all blanks, standards, quality controls, and samples are spiked with the internal standard prior to measurement. This method requires careful preparation to ensure consistent concentration across all solutions. Alternatively, the internal standard can be added online during measurement using a Y-connector. In this configuration, the internal standard solution is continuously mixed with each sample as it is introduced into the nebulizer. While this method simplifies preparation and reduces the risk of spiking errors, it introduces a dilution factor that must be considered.Practical examples show that correct implementation is crucial. Poor sample homogenization can lead to incorrect internal standard correction, particularly in challenging matrices such as mineral oils. If the sample is not homogeneous, the internal standard may not reflect the true behavior of the analytes, leading to misleading corrections. Therefore, careful sample preparation remains essential, even when internal standards are used.Internal standards also play a valuable role during method development. When establishing a new method, the internal standard can be used to verify matrix compatibility and recovery. Recovery tests with certified reference materials help determine whether matrix adaptation is necessary. If recovery is not satisfactory, matrix matching can be optimized through dilution strategies or calibration adjustments. Tools such as SemiQuant in<a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products/1489"> Qtegra software</a> can assist in identifying matrix components and guiding method optimization. Even if the internal standard is later omitted in routine operation, its use during development provides valuable insight into method robustness.It is worth noting that Argon, which is always present in the plasma, can act as a kind of “pseudo-internal standard”. While it does not replace a true internal standard element, monitoring the argon signal can provide useful information about plasma stability.In summary, internal standards are powerful tools for improving analytical reliability in ICP-OES. They help monitor and correct drift, improve precision, and increase confidence in results, especially in complex or variable matrices. However, they must be carefully selected, properly implemented, and understood in terms of their limitations. Used thoughtfully, internal standards strengthen both routine analysis and method development, contributing to consistent and trustworthy laboratory performance.<h3>Acknowledgement</h3>I would like to thank Dr. Torben Stichel, Dr. Joerg Axthelm and Dr. Sebastian Voelker Field Applications Scientist, Germany, Trace Elemental Analysis and for the support on this blog and the webinars.<h4>Sign up for our webinars live and on demand</h4><h5>English</h5><ul><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/5795">Lunch and Learn Tips and Tricks Series: Qtegra Part 1</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/5976">Lunch and Learn Tips and Tricks Series: Qtegra Part 2</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/5977">Lunch and Learn Tips and Tricks Series: Trace Elemental Analysis (ICP-OES &amp; ICP-MS)</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/5978">Trace Elemental Analysis: Ask the Expert</a></li></ul><h5>Deutsch</h5><ul><li>19. März 2026 <a target="_blank" rel="noopener noreferrer" href="https://event.on24.com/wcc/r/5179134/393E071E3B501943730958BA6203F477">Interne Standards in der ICP-OES: Ein Praxisguide für zuverlässige Qualitätssicherung im Labor</a></li><li>18. Juni 2026 <a target="_blank" rel="noopener noreferrer" href="https://event.on24.com/wcc/r/5179292/AE4C576B6A54D1AC182F7F77573D380F">Fehler reduzieren, Durchsatz steigern: Autoverdünnung mit PrepFast am ICP-MS</a></li><li>17. September 2026 <a target="_blank" rel="noopener noreferrer" href="https://event.on24.com/wcc/r/5179423/B5019C560431BADCA2A76E54E4EFE56F">ICP-OES smarter nutzen: Probendurchsatz erhöhen, Ressourcen sparen</a></li><li>17. Dezember 2026 <a target="_blank" rel="noopener noreferrer" href="https://event.on24.com/wcc/r/5179530/94EEDD1F56138F5EEE2AF24E29E6C12A">Qtegra ISDS Software Unlocked – Live im Expertengespräch</a></li></ul>Visit us on&nbsp;<a target="_blank" rel="noopener noreferrer" href="https://www.linkedin.com/showcase/72003132/admin/dashboard/">LinkedIn:</a>&nbsp;#ICP_OES #InternalStandards #ElementalAnalysis #TraceElementAnalysis<blockquote><h5>Petra Gerhards</h5>Petra Gerhards, Dipl-Ing, is Regional Marketing Manager of GC and GC-MS for EMEA at Thermo Fisher Scientific. She has more than 29 years of experience in the fields of GC-MS, SPE and LC-MS. Since joining the regional team she has contributed to workflow solutions combining vials and closures with SPE solutions, GC-MS and LC-MS. She works with KOL's on data for regional specific marketing campaigns, organizes in-house seminars and works on customer specific solutions. Her main expertise is in the field of doping and drugs-of-abuse analysis.</blockquote>

Internal Standards in ICP-OES: A Practical Guide to Better Accuracy and Precision

<h3>Introduction</h3><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_From_Raw_Signals_to_Reliable_Results_Post_Acquisition_Data_Workflows_in_ICP_Analysis_f7248bb920.jpg" alt="Thermo Fisher Scientific: From Raw Signals to Reliable Results: Post-Acquisition Data Workflows in ICP Analysis" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_From_Raw_Signals_to_Reliable_Results_Post_Acquisition_Data_Workflows_in_ICP_Analysis_f7248bb920.jpg 245w," sizes="100vw" width="1024" height="512">Modern elemental analysis techniques such as ICP-OES and ICP-MS are capable of generating large volumes of highly sensitive, multi-dimensional data in a single analytical run. These technologies are widely used across environmental, pharmaceutical, food, and materials science applications due to their precision and low detection limits. However, while significant emphasis is often placed on method development, instrument optimisation, and sample preparation, the true scientific value of any analysis is ultimately determined during the post-acquisition phase. It is here that raw instrumental signals are processed, interrogated, and validated before being translated into meaningful and defensible results. Whether you are working with the <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products?category=227&amp;instrumentationItems=84&amp;manufacturerItems=3&amp;search=iCAP+PRO">iCAP PRO ICP-OES</a>, the&nbsp;<a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products?category=232&amp;manufacturerItems=3&amp;search=iCAP+MX">iCAP MX ICP-MS</a>, the iCAP 7000 OES, or Qnova ICP-MS systems, the interface and workflow logic remain familiar.<h3>Method</h3>Following data acquisition, analysts must first navigate and organise complex datasets efficiently. Large analytical sequences may contain hundreds of samples, each with multiple analytes, replicates, and quality control elements. Tools such as column sorting and filtering are therefore essential for structured data interrogation. Sorting concentration values, for example, allows rapid identification of extreme values or potential outliers, while filtering by sample type, QC category, or analyte enables targeted investigation of specific data subsets. These tools support not only workflow efficiency but also statistical awareness, helping analysts detect trends, inconsistencies, or anomalies that may otherwise go unnoticed. In parallel, maintaining a complete LabBook history ensures that all changes to methods, calibration parameters, and analytical settings are recorded. This level of traceability is essential for regulatory compliance, particularly in environments operating under ISO standards or Good Laboratory Practice, and it ensures that results can be reproduced and audited with confidence.A fundamental aspect of post-acquisition processing is the application and evaluation of correction models. ICP-based techniques are inherently susceptible to a range of interferences, including background signals, spectral overlaps, and matrix-induced signal suppression or enhancement. Blank subtraction is typically the first correction applied, removing contributions from reagents, solvents, and instrument background. By comparing results with and without blank correction, analysts can assess the significance of background contributions, particularly at low concentration levels. In ICP-OES, Inter-element correction (IEC) addresses spectral interferences by mathematically compensating for overlapping emission lines, which is especially important in complex matrices containing multiple elements.&nbsp;For ICP-MS, correction equations can be similarly implemented to correct for the presence of an isobaric interferences of mass signals.Internal standard (IS) correction is another critical component, used to normalise signal fluctuations caused by instrument drift, variations in sample introduction, or matrix effects. Reviewing data with these corrections toggled on and off provides valuable diagnostic insight, allowing analysts to determine whether corrections are appropriate and whether the underlying method is robust.While processed concentration data is the primary output of most analyses, deeper insight can be gained by examining the underlying signal intensities. Replicate measurements, for instance, provide a direct assessment of analytical precision. Consistent replicate signals indicate stable measurement conditions, whereas significant variation may suggest issues such as sample heterogeneity, nebuliser instability, or matrix interference. Similarly, blank intensities can reveal contamination or insufficient rinsing between samples, often serving as an early indicator of systematic error. In ICP-OES, spectral sub-array views allow analysts to visualise the emission profile around a selected wavelength, enabling verification of peak shape, background correction points, and potential spectral overlaps. In ICP-MS, attention must be given to detector behaviour, particularly when signals transition between pulse and analog modes at higher concentrations. Such transitions can introduce non-linearity into calibration curves, sometimes necessitating cross-calibration to maintain quantitative accuracy.Calibration is central to transforming raw signal intensity into quantitative concentration data, and its evaluation is one of the most critical steps in the workflow. Several performance indicators are used to assess calibration quality. The coefficient of determination (R²) provides a measure of how well the calibration model fits the data, though a high R² alone does not guarantee accuracy. Bias offers insight into systematic deviations between expected and measured values, highlighting potential issues with standards or instrument response. Detection limits, including the limit of detection (LOD) and instrument detection limit (IDL), define the sensitivity of the method, while background equivalent concentration (BEC) reflects the contribution of background signal to the overall measurement. A comprehensive calibration assessment requires consideration of all these parameters together, rather than reliance on a single metric. In addition, quality control samples—such as calibration check standards (CCVs), certified reference materials (CRMs), and matrix spikes—are used to verify accuracy and method performance. Automated flagging of QC results that fall outside predefined acceptance criteria provides an efficient means of identifying non-compliant data and supports rapid decision-making.Equally important is the evaluation of instrument performance through diagnostic readbacks recorded during the analysis. These parameters provide insight into the physical and operational state of the instrument at the time of measurement. For ICP-MS, key readbacks include nebuliser gas pressure, vacuum levels, and interface conditions. Changes in these parameters can indicate issues such as partial blockages, salt deposition, or vacuum degradation. Similarly, plasma-related parameters and gas flow stability are critical indicators in both ICP-OES and ICP-MS systems. By correlating readback trends with analytical results, analysts can identify the root causes of anomalies, distinguish between instrument-related and sample-related issues, and take corrective action where necessary. This diagnostic capability is particularly valuable when troubleshooting unexpected results or when sharing data with technical support teams for further investigation.Once the data has been thoroughly reviewed and validated, the final step is to export and communicate the results in a clear and usable format. Structured reporting tools enable the generation of comprehensive summaries that include concentration data, calibration details, quality control results, and any associated flags or annotations. These reports are essential for documentation, regulatory submissions, and communication with stakeholders. For greater flexibility, exporting data in CSV format allows integration with external tools such as spreadsheet software, statistical analysis platforms, or laboratory information management systems (LIMS). This interoperability facilitates advanced data analysis, long-term data storage, and seamless integration into broader laboratory workflows.<h3>Conclusion</h3>In conclusion, post-acquisition data processing is not merely a procedural step but a critical component of the analytical workflow that determines the reliability and scientific validity of results. Through careful organisation of data, rigorous application of correction models, detailed evaluation of calibration performance, and continuous monitoring of instrument diagnostics, analysts can ensure that their results are both accurate and defensible. As analytical technologies continue to evolve and datasets become increasingly complex, the importance of robust and systematic data evaluation will only grow. Mastery of these workflows transforms raw instrumental signals into high-quality scientific information, underpinning confident decision-making across a wide range of applications.<h3>Acknowledgement</h3>I would like to thank&nbsp;Matthew Gregory&nbsp;Field Applications Scientist, North EMEA, Trace Elemental Analysis and&nbsp;David Fishwick&nbsp;Field Applications Scientist, North EMEA, Trace Elemental Analysis for the support on this blog and the webinars.Sign up for our webinars live and on demand.English<ul><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/5795">Lunch and Learn Tips and Tricks Series: Qtegra Part 1</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/5976">Lunch and Learn Tips and Tricks Series: Qtegra Part 2</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/5977">Lunch and Learn Tips and Tricks Series: Trace Elemental Analysis (ICP-OES &amp; ICP-MS)</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/5978">Trace Elemental Analysis: Ask the Expert</a></li></ul>Deutsch<ul><li>19. März 2026 <a target="_blank" rel="noopener noreferrer" href="https://event.on24.com/wcc/r/5179134/393E071E3B501943730958BA6203F477">Interne Standards in der ICP-OES: Ein Praxisguide für zuverlässige Qualitätssicherung im Labor</a></li><li>18. Juni 2026 <a target="_blank" rel="noopener noreferrer" href="https://event.on24.com/wcc/r/5179292/AE4C576B6A54D1AC182F7F77573D380F">Fehler reduzieren, Durchsatz steigern: Autoverdünnung mit PrepFast am ICP-MS</a></li><li>17. September 2026 <a target="_blank" rel="noopener noreferrer" href="https://event.on24.com/wcc/r/5179423/B5019C560431BADCA2A76E54E4EFE56F">ICP-OES smarter nutzen: Probendurchsatz erhöhen, Ressourcen sparen</a></li><li>17. Dezember 2026 <a target="_blank" rel="noopener noreferrer" href="https://event.on24.com/wcc/r/5179530/94EEDD1F56138F5EEE2AF24E29E6C12A">Qtegra ISDS Software Unlocked – Live im Expertengespräch</a></li></ul><blockquote>Visit us on&nbsp;<a target="_blank" rel="noopener noreferrer" href="https://www.linkedin.com/showcase/72003132/admin/dashboard/">LinkedIn:</a>&nbsp;#AnalyticalChemistry #ICPMS #ICPOES #DataAnalysis</blockquote>

From Raw Signals to Reliable Results: Post-Acquisition Data Workflows in ICP Analysis

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