Comprehensive two-dimensional (2D) chromatography method combining LC, SFC, and HRMS with fragmentation (LC×SFC-HRMS/MS) was developed for structural characterisation of lignin.

In this study, we analyzed 64 human serum samples representing three different groups of colorectal cancer using cutting edge GC×GC–LR/HR-TOFMS techniques.

Characterization of plastic-derived pyrolysis oils and the comparison of polar-nonpolar and nonpolar-polar column sets increasing chromatographic resolution in different regions of the structured chromatograms.

The aim of this presentation is to elucidate the potentiality of coupling HCC-HS with GC and its further development to answer food-related questions.

Demonstration of improved workflow for identification and quantification of individual species in a fragrances, using a prototype GCxGC-TOFMS/FID instrument.

We present the combination of Vac-SPME and MC-SPME into Vac-MC-SPME, along with the enhanced separation capability provided by GC×GC and advanced tile-based data handling.

We aim to simplify complex data to elucidate high-level mechanisms of engineering processes using non-targeted (NT) analysis by two-dimensional gas chromatography coupled with mass spectrometry (GCxGC-MS).

This work aimed to verify compliance and validate the performance of two-dimensional gas chromatography coupled to mass spectrometry in different laboratories by monitoring probe metabolites in exhaled breath.

Two-dimensional gas chromatography (GC×GC) methodology, with dedicated sample preparation techniques, has been applied to investigate lipid fractions - total fatty acid profile and minor lipid components.

In the first, part we will summarize why GC×GC has not yet become established in the pharmaceutical field. In the second part, we will present how GC×GC-HRMS was used to investigate the active API.