Enabling Routine and Reproducible Intact Mass Analysis When Data Integrity Matters

Meeting the Challenges of Implementing Accurate-Mass Mass Spectrometry for Biotherapeutic Development in Regulated/non-Regulated Environments Henry Shion; Nilini Ranbaduge; Ximo Zhang; Ying Qing Yu; Weibin Chen; and Scott Berger Waters CorporaƟon, Milford , MA, USA INTRODUCTION    Despite the…

Application Note Greener, Lower Cost Organic Mobile Phase Solvents for the LC-MS Analysis of Intact Biotherapeutic Proteins Henry Shion, Ying Qing Yu Waters Corporation Abstract This application note presents on the recent trend replacing acetonitrile (Class II Toxicity) with greener…

Application Note INTACT Mass™ - a Versatile waters_connect™ Application for Rapid Mass Confirmation and Purity Assessment of Biotherapeutics Henry Shion, Patrick Boyce, Scott J. Berger, Ying Qing Yu Waters Corporation Abstract In recent years, liquid chromatography-mass spectrometry (LC-MS) intact mass…

[ TECHNOLOGY BRIEF ] Evaluating BioAccord LC-MS System Performance for Deployment of a Compact, SmartMS-Enabled Biopharma Solution in Late Stage Development and QC Environment – Intact Mass Analysis Henry Shion, Jonathan Pugh, Jill Lord, Yun Alelyunas, Ying Qing Yu and…