A WORKFLOW DRIVEN PLATFORM SOLUTION FOR MAM-BASED CRTICAL QUALITY ATTRIBUTE MONITORING OF BIOTHERAPEUTICS IN PROCESS DEVELOPMENT AND QC

POSTER T1530-06-41 Simplifying workflows for MAM-based critical quality attribute monitoring of biotherapeutics in process development and QC using a novel LCMS platform Scott J Berger, Nilini Ranbaduge, Ying Qing Yu, Min Du, Weibin Chen Waters Corporation, Milford, MA CONTACT INFORMATION:…

[ APPLICATION NOTEBOOK ] Multi-Attribute Methods for Biopharmaceutical Analysis Application Notes [ APPLICATION NOTEBOOK ] Introduction The adoption of LC-MS-based multi-attribute method (MAM) analysis for routine monitoring of biotherapeutic variation has progressed greatly over the last five years. The ability…

PEPTIDE CHARACTERIZATION AND MONITORING WORKFLOW FOR BIOSIMILAR mAb DRUG PRODUCTS USING A COMPLIANCE READY LC-MS AND INFORMATICS PLATFORM 20221115_Remicade T0_200ng_03 2 TOF MSe (50 2000) 6V ESI (BPI) 1/2 20221115_Inflectra T0_200ng_12 2 TOF MSe (50 2000) 6V ESI (BPI) Kellen…

[ TECHNOLOGY BRIEF ] Routine Peptide Mapping Analysis using the BioAccord System Nilini Ranbaduge, Henry Shion, and Ying Qing Yu Waters Corporation, Milford, MA, USA SmartMS-enabled BioAccord System improves the operational efficiency for routine peptide mapping analysis. GOAL Demonstrate how…