Monoclonal Antibody Charge Variants Identification by Fully Automated Capillary Isoelectric Focusing – Mass Spectrometry

Application Note Biotherapeutics and Biosimilars Identification of NISTmAb Charge Variants by Fully Automated Capillary Isoelectric Focusing and Mass Spectrometry Authors James Xia, Rena Wang CMP Scientific Corp. Brooklyn, NY, USA Jens Meixner Agilent Technologies, Inc. Waldbronn, Germany Introduction The NIST…

Application Note Biopharmaceuticals Charge Variant Analysis of Monoclonal Antibodies and ADCs Using CE/MS Separation and qualitative analysis using CIEF/Q-TOF for characterizing charge variants in Humira and Kadcyla Authors Abstract Yifan Wang and Lian Yang CMP Scientific Corp. Shanghai, China This…

Comparison of Different Brands of Carrier Ampholytes for Monoclonal Antibody Charge Heterogeneity Analysis by Capillary Isoelectric Focusing Application Note Biotherapeutics & Biosimilars Author Abstract Christian Wenz This Application Note compares the performance of four commercially available Agilent Technologies, Inc. brands…

Separation of Native Monoclonal Antibodies and Identification of Charge Variants: Teamwork of the Agilent 3100 OFFGEL Fractionator, Agilent 2100 Bioanalyzer and Agilent LC/MS Systems Application Note Biosimilar and Biotherapeutics Authors Abstract Suresh Babu CV and Charge variants due to post-translational…