Charge Variant Analysis of Monoclonal Antibodies and ADCs Using CE/MS

Application Note Biotherapeutics and Biosimilars Identification of NISTmAb Charge Variants by Fully Automated Capillary Isoelectric Focusing and Mass Spectrometry Authors James Xia, Rena Wang CMP Scientific Corp. Brooklyn, NY, USA Jens Meixner Agilent Technologies, Inc. Waldbronn, Germany Introduction The NIST…

Application Note Pharma & Biopharma Monoclonal Antibody Charge Variants Identification by Fully Automated Capillary Isoelectric Focusing – Mass Spectrometry Authors Tony Wang, James Xia, and Rena Wang CMP Scientific Corp, Brooklyn, NY, USA Jens Meixner Agilent Technologies, Inc. Waldbronn, Germany…

Charge Heterogeneity Analysis of Intact Infliximab Using CESI-MS and Neutral OptiMS Cartridge Fang Wang1, Tingting Li1, Esme Candish2 1 SCIEX, Brea, CA; 2SCIEX, Framingham, MA; Key Features • Capillary zone electrophoresis (CZE) separation and Mass spectrometric (MS) identification of charge…

Separation of Native Monoclonal Antibodies and Identification of Charge Variants: Teamwork of the Agilent 3100 OFFGEL Fractionator, Agilent 2100 Bioanalyzer and Agilent LC/MS Systems Application Note Biosimilar and Biotherapeutics Authors Abstract Suresh Babu CV and Charge variants due to post-translational…