Characterization of Monoclonal Antibody Biosimilar through C-terminal and Disulfide Bond Peptides Sequencing Analysis on Q-TOF Mass Spectrometer

Application News AD-0190 Biopharma / LCMS-9030 Characterization of C-terminal and Disulfide Bond Peptides of Monoclonal Antibody (mAb) on Q-TOF Mass Spectrometer Udi Jumhawan and Zhaoqi Zhan Application Development & Support Centre, Shimadzu (Asia Pacific), Singapore 1. Introduction In recent years,…

RES MS analysis of antibodies at the protein and peptide levels is critical during development and production of biopharmaceuticals. The compositions of current generation therapeutic proteins are often complex due to their heterogeneity caused by various modifications which are relevant…

APPLICATION BRIEF 73556 Confident peptide mapping and disulfide bond analysis of an IgG2 monoclonal antibody Authors: Sara Carillo and Jonathan Bones NIBRT – The National Institute for Bioprocessing Research and Training, Dublin, Ireland [email protected] Tom Buchanan, Thermo Fisher Scientific Keywords:…

Application News AD-0176 Biopharma / Nexera Bio & Q-TOF LCMS-9030 Peptide Mapping of Monoclonal Antibody (mAb) Using Nexera Bio with Q-TOF Mass Spectrometer for Full Sequence Confirmation Udi Jumhawan, Wan Tung Liw, Jie Xing and Zhaoqi Zhan Application Development &…