A Novel Instrumental Strategy for Parallel Reaction Monitoring of Intact Proteins with an Orbitrap Analyzer

Advances in Orbitrap Instrumentation for Native Top-Down Analysis of Non-Covalent Protein Complexes Eugen Damoc1, Rosa Viner2, Albert Konijnenberg3, Kyle Fort1, Maria Reinhardt-Szyba1, Mikhail Belov1, Alexander Makarov1. 1Thermo Fisher Scientific, Bremen, Germany; 2Thermo Scientific, San Jose, CA; 3Thermo Fisher Scientific, Eindhoven,…

TECHNICAL NOTE 65379 Advancing native top-down MS analysis of non-covalent protein complexes: The Thermo Scientific Q Exactive UHMR mass spectrometer Authors Eugen Damoc, Kyle Fort, Maria Reinhardt-Szyba, Mikhail Belov, Alexander Makarov; Thermo Fisher Scientific, Bremen, Germany Rosa Viner; Thermo Fisher…

Go beyond what you thought possible with native MS Thermo Scientific Q Exactive UHMR Hybrid Quadrupole-Orbitrap mass spectrometer Gain deeper insight into native proteins Native mass spectrometry (MS) is a powerful technique for studying the structure of large protein complexes,…

A Complete Workflow Solution for Intact Monoclonal Antibody Characterization Using a New High-Performance Benchtop Quadrupole-Orbitrap LC-MS/MS Zhiqi Hao,1 Yi Zhang,1 David Horn,1 Seema Sharma,1 Shiaw-Lin Wu, 2 Irene Ae-Ning Lin, 3 Yi-Hsuan Pan, 3 Ya-Fen Yang, 3 and Andreas F.…