Advances in Orbitrap Instrumentation for Native Top-Down Analysis of Non-Covalent Protein Complexes

TECHNICAL NOTE 65379 Advancing native top-down MS analysis of non-covalent protein complexes: The Thermo Scientific Q Exactive UHMR mass spectrometer Authors Eugen Damoc, Kyle Fort, Maria Reinhardt-Szyba, Mikhail Belov, Alexander Makarov; Thermo Fisher Scientific, Bremen, Germany Rosa Viner; Thermo Fisher…

Go beyond what you thought possible with native MS Thermo Scientific Q Exactive UHMR Hybrid Quadrupole-Orbitrap mass spectrometer Gain deeper insight into native proteins Native mass spectrometry (MS) is a powerful technique for studying the structure of large protein complexes,…

ex ex co filter in a quadrupole-Orbitrap hybrid Mass Spectrometer Results: Viability of the concept is explored using simulation and initial experiments FI m Introduction Recent advances in top-down analysis of intact proteins were largely driven by improving of liquid…

PRODUCT SPECIFICATIONS Q Exactive UHMR Hybrid Quadrupole-Orbitrap mass spectrometer Delivering unmatched identification and characterization Keywords Orbitrap technology, Q Exactive family, accurate mass, high resolution, native ms, ultra-high mass range Benefits • U  ltra-high mass range up to m/z 80,000…