Kinase inhibition screening by label-free mass spectrometry employing the MALDI PharmaPulse HTS solution

Label-free compound profiling in K562 leukemia cells by MALDI-TOF mass spectrometry using heme B as response marker Bruker’s very fast rapifleX MALDI PharmaPulse solution has been successfully used in pharmaceutical research for compound screening in various cell-free biochemical assays that…

Label-free drug uptake analysis of whole cells by MALDI-TOF mass spectrometry using the transport protein OATP2B1 as an example In this application note, we demonstrate a MALDI MS cellular drug uptake and inhibition assay [1]. It was conducted in HEK293…

Profiling mammalian cell differentiation by MALDI-TOF MS: Developing a highly reproducible and robust sample preparation workflow In this application note, we present a universal workflow for mammalian cell MALDI-TOF MS analysis in order to distinguish between ground-state naïve and differentiating…

Novel MALDI-TOF MS Workflow for Ultrahigh-Throughput Screening of Different Analytes at Each Position on a Plate Novel Synthesis Screening workflow in MALDI PharmaPulse software that was developed for screening of synthetic chemical reactions is applied to screen a custom library…