Advanced Oligonucleotide Characterization Using Multi-Reflecting Time-of-Flight Technology

MEETING DEMANDS FOR IMPROVED MS PERFORMANCE TO SUPPORT DEEPER PRODUCT LC-MS CHARACTERIZATION WITH MULTI-REFLECTING TOF MS TECHNOLOGY Jonathan Fox1, Scott Berger2, Nick Pittman1, Ying Qing Yu2 1Waters Corporation, Wilmslow, Cheshire, UK, 2Waters Corporation, 34 Maple Street, Milford MA, USA. INTRODUCTION…

Application Note Oligo Mapping of sgRNA Digests: Leveraging Xevo MRT Mass Spectrometer Performance and Streamlining Data Analysis Catalin Doneanu, Alexandre F Gomes, Tatiana Johnston, Chris Preston, Matt Gorton, Bala Addepalli, Scott Berger, Ying Qing Yu Waters Corporation, Milford, MA, United…

Application Note Advanced Monoclonal Antibody Peptide Mapping Using Multi-Reflecting TOF MS Technology Jonathan Fox, Ying Qing Yu, Scott J. Berger, Nick Pittman Waters Corporation This is an Application Brief and does not contain a detailed Experimental section. Abstract Peptide mapping…

Application Note Quantifying Oligonucleotide Deamination with Multi-Reflecting Time-of-Flight Mass Spectrometry Jo-Anne Riley, Jonathan Fox, Laetitia Denbigh, Scott Berger, Nick Pittman, Ying Qing Yu Waters Corporation, United States Published on September 09, 2025 Abstract In this study, the identification and quantification…