Targeted Genomic and Epigenomic Dual Analysis of the Same Region for an Entire Gene in Tumor DNA

Molecular Subtypes in Glioblastoma Multiforme: Integrated Analysis Using Agilent GeneSpring and Mass Profiler Professional Multi-Omics Software Application Note Authors Abstract Durairaj Renu, Pritha Aggarwal, Agilent GeneSpring and Mass Profiler Professional (MPP) software was used Sunil C. Cherukuri, and Pramila Tata…

0 Introduction 100 80 Relative Abundance Synthetic ONs with different functionalities including antisense ONs, small interfering RNAs (siRNAs), aptamers and immunostimulatory RNAs (isRNAs) are candidate therapeutic agents due to their specificity, and well-established synthesis and modification technologies. Still characterization is…

Application Note High-throughput Analysis of DNA-Modifying Enzymes by an Agilent RapidFire System Author Peter Rye Agilent Technologies, Inc. Abstract Enzymes that act on DNA are promising targets for anticancer therapeutics.1 For example, the epigenetic enzyme DNMT1 is inhibited by 5-azacytidine,…

Fluorescence measurement of hybridization between quencher (DABCYL) labelled PNA probes and a fluoresceine labelled DNA using the Fluorescence BioMelt Package Application Note Author Katherine Lighton, Agilent Technologies, Inc. Mulgrave, Victoria 3170, Australia. Mark J. Fiandaca, Boston Probes, Bedford, Massachusetts 01730,…