High Resolution LC/MS Analysis of Therapeutic Oligonucleotides on a New Porous Polymer-Based Reversed Phase Column

Thermo Scientific DNAPac Family of Columns Superior Oligonucleotide Analysis DNAPac RP 2016 DNAPac PA200 RS 2013 DNASwift SAX-1S 2009 For over 30 years, the Thermo Scientific™ DNAPac™ family of columns has been the go-to for high resolution U/HPLC separation of…

DNAPac RP column Wide-ranging polynucleotide separation capabilities using Reversed Phase particles with variable pore geometry Christof Mitterer1, Mauro De Pra2, Shanhua Lin3, Shane Bechler3, Simonas Balčiūnas4, James Peterman3, Simonas Dapkus5, Binalkumari Mistry3, Brandon Robson3, Matas Damonskis5 1Thermo Fisher Scientific Langerwehe,…

APPLICATION NOTE 73870 Identification and quantitation of oligonucleotides, impurities, and degradation products Haichuan Liu1, Kevin Guo2, Jennifer Sutton1, Keeley Murphy1, Min Du2 1 Thermo Fisher Scientific, San Jose, CA 2 Thermo Fisher Scientific, Boston, MA Keywords: Oligonucleotide, RNA, impurity, purification,…

APPLICATION BRIEF 74058 Characterization of a synthetic double stranded siRNA using high-resolution mass spectrometry Authors: Haichuan Liu1, Kevin Guo2, Julia Baek3, Jennifer Sutton1, Keeley Murphy1, Min Du2 Thermo Fisher Scientific, San Jose, CA 1 2 Thermo Fisher Scientific, Cambridge, MA…