Rapid Identification of the In Vivo Biotransformations of a Targeted Protein Degrader (PROTACs) Using Xevo G3 QTof and waters_connect Software Platform

Rapid Determination Of The Pharmacokinetics, Metabolism, Elimination And Tissue Distribution Of A PROTACs Drug Using UHPLC-MS/MS, HRMS And DESI Imaging. Abstract ID number: 322535 Authors: 1Andrew Leightner, 1Steven K Lai, 1Anthony Midey, 1Robert S Plumb, 2Ian D Wilson Affiliations: 1Waters…

Application Note A Rapid UPLC™-MS/MS Method for the Quantification of PROTACs-3-Gefitinib and Urinary Metabolites Following Subcutaneous Administration to Male Rats Robert S. Plumb, Nikunj Tanna Waters Corporation Abstract Proteolysis Targeting Chimera (PROTAC) drugs are now well established in pharmaceutical development…

Application Note Rapid High Sensitivity LC-MS/MS Bioanalytical Method for the Simultaneous Quantification of Gefitinib Based PROTACs – 3 and Gefitinib in Rat Plasma to Support Discovery DMPK Studies Robert S. Plumb Waters Corporation This is an Application Brief and does…

Application Note Rapid, High Sensitivity Quantification of a Proteolysis Targeting Chimera, PROTAC, in Rat Plasma From a Microsampling DMPK Study Using UPLC-MS/MS Robert S. Plumb Waters Corporation Abstract Proteolysis targeting chimeras are bifunctional molecules with two molecular entities connected by…