Higher Order Protein Structure Elucidation by HDX-MS

TECHNICAL NOTE 65887 Hydrogen deuterium exchange mass spectrometry for protein structural characterization Authors: Terry Zhang and Rosa Viner Thermo Fisher Scientific, San Jose, CA, USA Keywords: Peptide mapping, protein conformation, bottom-up, deuterium uptake, hydrogen deuterium exchange mass spectrometry, HDX-MS, HDX,…

Notch3 Epitope Mapping using Integrated Structural Proteomic Techniques Terry Zhang1, Leigh Foster2, Ryan Bomgarden2, Veronica Saenz-Vash3, Huili Zhai3, Rosa Viner1, 1Thermo Fisher Scientific, San Jose, CA;2 Rockford, IL, 3Novartis Research Institute, Cambridge, MA ABSTRACT RESULTS Purpose: Perform epitope mapping in…

APPLICATION NOTE 65888 Structural characterization of the therapeutic antibody and biosimilar product with hydrogen deuterium exchange mass spectrometry Authors: Terry Zhang and Rosa Viner Thermo Fisher Scientific, San Jose, CA, USA Keywords: Peptide mapping, protein conformation, bottom-up, trastuzumab, biosimilar, deuterium…

Poster # P-I-0178 Probe the protein conformation using top-down hydrogen exchange mass spectrometry at higher resolution with electron transfer dissociation Yuqi Shi1, Graeme McAlister1, Rosa Viner1, 1Thermo Fisher Scientific, San Jose, CA Abstract Results Purpose: Study protein, protein/complex conformations by…