Optimizing Sample Preparation Protocols for Extraction of a Panel of PROTACs Molecules From Biological Fluids

Application Note Rapid, High Sensitivity Quantification of a Proteolysis Targeting Chimera, PROTAC, in Rat Plasma From a Microsampling DMPK Study Using UPLC-MS/MS Robert S. Plumb Waters Corporation Abstract Proteolysis targeting chimeras are bifunctional molecules with two molecular entities connected by…

Application Note A Simplified Approach to Optimizing the Oasis PRiME HLB 2 Step Protocol to Maximize Recoveries Nikunj Tanna, Chelsea Plummer Waters Corporation Abstract Oasis™ PRiME HLB SPE removes >95% phospholipids from biological matrices, while maintaining the reversedphase selectivity of…

[ APPLICATION NOTEBOOK ] Versatile LC-MS/MS Solutions for the Evolving Bioanalysis Landscape Small Molecules Oligonucleotide Protein/Peptide Therapeutics Software Tools Targeted Imaging LC-MS/MS Solutions to Support Reliable, Sensitive and Efficient Workflows for the Bioanalysis of Drug Modalities Welcome to the Waters…

Application Note Oasis™ PRiME HLB Solid Phase Extraction for High Bioanalytical Plasma Analyte Recovery and Low Matrix Effects of Top-Selling Pharmaceuticals Mary Trudeau, Margot Lee Waters Corporation Abstract The following work demonstrates a simple, generic, and broadly applicable sample preparation…