Characterizing Protein–Protein Interactions via Static Light Scattering: Nonspecific Interactions

PEG-Protein Interactions for Stable Formulations Studied by CG-MALS Daniel Some and Sophia Kenrick, Wyatt Technology Corp., Santa Barbara, CA 93117 1. Background Many therapeutic proteins such as antibodies exhibit non-specific self-association at concentrations > 10 mg/mL typical of final drug-product…

A P P L I C AT I O N N O T E AN3009: Characterization of self-associating antibody solutions at high concentrations with CG-MALS Sophia Kenrick, Ph.D. and Daniel Some, Ph.D., Waters | Wyatt Technology Summary The characterization of…

A P P L I C AT I O N N O T E AN3007: Estimating protein partitioning in multicomponent aqueous two-phase extraction based on CG-MALS measurements Christian Kress, Ph.D. and Christoph Brandenbusch, Ph.D., Technical University of Dortmund Summary This…

Volume 28, Number 1 Technical Article by Dan Some and Amy Hanlon Characterizing Protein–Protein Interactions Via Static Light Scattering: Inhibition Kinetics and Dissociation Q uantification of the kinetic rates of protein association, dissociation, and aggregation is an essential factor in…